| 外周血白细胞与糖尿病肾病进展关系的研究 |
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| 引用本文： | 张雪扬,刘晓真,白然,王咏波,杜建玲,李昌臣.外周血白细胞与糖尿病肾病进展关系的研究[J].中华全科医师杂志,2012(7):528-529. |
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| 作者姓名： | 张雪扬 刘晓真 白然 王咏波 杜建玲 李昌臣 |
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| 作者单位： | 116011,大连医科大学附属第一医院内分泌科 |
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| 摘 要： | 将473例肌酐正常的2型糖尿病肾病（DN）患者根据尿白蛋白／肌酐分为微量白蛋白尿组（DNl组，246例）和大量白蛋白尿组（DN2组，227例），结果显示，DN2组WBC、单核细胞、CRP较DNl组显著增加（6．8±1．7）×109／L比（6．3±1．5）×109／L，（0．49±0．23）×109／L比（0．32±0．21）×109／L，（4．1±1．1）mg／L比（1．7±0．3）mg／L，均P〈0．05]。多元线性回归分析显示，WBC、单核细胞、LDL—C和淋巴细胞是尿白蛋白／肌酐升高的独立影响因素。
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| 关 键 词： | 糖尿病肾病 白细胞 |
Association of peripheral white blood cell with type 2 diabetic nephropathy |
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| ZHANG Xue-yang
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LIU Xiao-zhen
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BAI Ran
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WANG Yong-bo
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DU Jian-ling
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LI Chang-chen.Association of peripheral white blood cell with type 2 diabetic nephropathy[J].Chinese JOurnal of General Practitioners,2012(7):528-529. |
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| Authors: | ZHANG Xue-yang LIU Xiao-zhen BAI Ran WANG Yong-bo DU Jian-ling LI Chang-chen |
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| Institution: | Department of Endocrinology, First Affiliated Hospital, Dalian Medical University, 116011, China |
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| Abstract: | A total of 473 patients of diabetic nephropathy （DN） with normal serum creatinine were recruited. Blood routine, blood lipids and urine albumin/creatinine ratio （UACR） were measured. They were divided into microalbuminuria group （ DN1, n = 246 ） and macroalbuminuria group （ DN2, n = 227 ）. The white blood cell （WBC） count, monocyte count and CRP significantly increased with the progression of DNintheDN2 group versus those in the DN1 group （6.8 ±1.7） ×109/L vs. （6.3 ± 1.5）×109/L, （0.49±0.23）×109/Lvs. （0.32±0.21）×109/L,（4.1 ±1.1）mg/L vs, （1.7 ±0.3） mg/L, allP〈 0. 05]. According to multiple linear regression analysis, WBC, monoeyte, low density lipoprotein- cholesterol and lymphocyte were found to be independent influencing factors for the elevation of UACR. |
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| Keywords: | Diabetic nephropathies Leukocytes |
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