不同血栓栓塞危险分层心房颤动患者微栓子及血浆D-二聚体水平观察

持续性心房颤动（房颤）患者216例根据房颤血栓栓塞危险分层CHADS2评估系统评分，分别按0～6分逐一分组，是否≥2分分为两组，应用经颅多普勒检查微栓子及免疫比浊法测定D-二聚体。结果显示，随CHADS2评分分值增加，监测到的微拴子数量及D-二聚体水平有增加趋势，0分、1分组微栓子数量及D-二聚体水平显著低于其他高分值组（P〈0．05），5分、6分组微栓子数量显著高于其他分值组（P〈0．05）；CHADS2评分≥2分组微栓子检出数量及D-二聚体水平显著高于〈2分组（P〈0．01）。提示，微栓子及血浆D-二聚体水平可反映房颤患者发生血栓栓塞的危险性。

D-dimer levels and the numbers of micro-embolic signals in non-valvular atrial fibrillation patients as classified by thromboembolic risk score

To observe the D-dimer levels and the numbers of miero-embolic sigtmls （MES） in atrial fibrillation patients with different thromboembolie risk scores. A total of 216 persistent atrial patients were classified according to their different scores with a range of 0 -6. They were also divided into two groups by ≥2 or 〈 2 according to the CardiaeFailure, Hypertension, Age, Diabetes, Stroke 2 （CHADS2） point system, D-dimer levels and the numbers of MES were deteeted in all patienls. A rising trend of D-dimer level and the number of MES was observed with the inereases of CttADSz score. D-dimer level and the number of MILS in group 0 or 1 score were significantly lower than those in other high score groups （ P 〈 0. 05）. And the number of MES in group 5 or 6 score was significantly higher than those in other low score groups （P 〈0.05）. D-direct level and the number of MES in the group of ≥ 2 score were significantly higher than those in group 〈 2 score （P 〈 0. 01）. It suggests that D-dimer level and the number of MES may reflect the thromboembolic risks in atrial fibrillationi patients.