舒肝宁与门冬氨酸鸟氨酸对改善小儿急性黄疸型肝炎的疗效比较

目的 评价舒肝宁与门冬氨酸鸟氨酸对改善小儿急性黄疸型肝炎肝功能及凝血功能的效果.方法 选取湖北省恩施土家族苗族自治州民族医院儿科自2014年6月至2016年6月收治的80例小儿急性黄疸型肝炎,采取随机数字表法分为观察组与对照组,每组各40例,观察组给予舒肝宁注射液治疗,对照组给予门冬氨酸鸟氨酸治疗,对比两组患儿疗效、肝功能及凝血指标变化.结果 观察组临床总有效率为100.00％,对照组临床总有效率为80.00％,观察组显著高于对照组,差异具有统计学意义(x2=6.74,P＜0.05).两组患儿治疗后与治疗前相比总胆红素、ALT及AST水平均显著降低(f=3.98～6.38,均P＜0.05),观察组与对照组相比,上述指标降低更加显著,差异具有统计学意义(f值分别为4.75、5.78、5.55,均P＜0.05).两组患儿治疗后与治疗前相比,APTT及PT均显著降低(t=4.23 ～6,12,均P＜0.05),PLT均显著升高(t值分别为5.11、6.48,均P＜0.05),观察组与对照组相比上述指标变化更加显著,差异具有统计学意义(t值分别为5.11、5.68、5.88,均P＜0.05).两组间不良反应发生率比较差异无统计学意义(x2=0.35,P＞0.05).结论 舒肝宁注射液治疗小儿急性黄疸型肝炎的临床疗效优于门冬氨酸鸟氨酸,可有效改善患儿的肝功能及凝血功能指标.

Comparison of clinical efficacy of Shuganing injection and ornithine aspartate injection on improving pediatric jaundice hepatitis

Objective To evaluate the effect of ornithine aspartate injection and Shuganing injection on improving the liver function and blood coagulation tunction for pediatric jaundice hepatitis.Methods From June 2014 to June 2016 totally 80 cases with pediatric jaundice hepatitis treated in Enshi Tujia and Miao Autonomous Prefecture Hospital were selected and were divided into control group and observation group according to random number table with 40 cases in each group.The control group was given ornithine aspartate injection while the observation group was given Shuganing injection.Curative effect,liver function and blood coagulation index were compared between two groups.Results The total effective rate of the control group and the observation group were 80.00％ and 100.00％,respectively,and it was significantly higher in the observation group than in the control group (x2 =6.74,P ＜ 0.05).The total bilirubin (TBil),ALT and AST levels of two groups declined after treatment (t value ranged 3.98-6.38,all P ＜ 0.05),and the decline in the observation group was more remarkable with statistically significant difference (t value was 4.75,5.78 and 5.55,respectively,all P ＜ 0.05).The APTT and AST decreased in two groups after treatment (t value ranged 4.23-6.12,all P ＜ 0.05),but PLT increased in two groups (t value was 5.11 and 6.48,respectively,both P ＜ 0.05).The changes of the above indexes in the observation group were more remarkable than the control group with significant differences (t value was 5.11,5.68 and 5.88,respectively,all P ＜ 0.05).The incidence of adverse reactions in two groups were not statistically different (x2 =0.35,P ＞ 0.05).Conclusion Shuganning injection can achieve better clinical efficacy than ornithine aspartate injection in treating pediatric jaundice hepatitis,and it can improve liver function and coagulation function effectively.