小儿支气管哮喘血T、B淋巴细胞异常表达的临床意义

目的 探讨小儿支气管哮喘血T、B淋巴细胞异常表达的临床意义.方法 选择2016年1至10月在雅安市人民医院就诊的哮喘患儿198例为研究对象(哮喘组),按照1:1配对,随机选取同期体检儿童为对照组;在哮喘组患儿中急性发作期107例,缓解期91例,对照组198例.检测哮喘急性发作、哮喘缓解和对照组儿童外周血的T淋巴细胞(CD3、CD3+ CD4+、CD3+ CD8+和CD4+/CD8+)、B淋巴细胞(CD19+ CD23+),比较其相关指标的差异.结果 哮喘组急性发作期患儿的CD3+ CD4+、CD19+ CD23+分别明显高于哮喘缓解期(f值分别为2.479和2.341,均P＜0.05)和对照组的患者(t值分别为2.421和2.524,均P＜0.05);哮喘组急性发作期患儿的CD4+/CD8+明显高于哮喘缓解期的患儿和对照组,经比较均有显著性差异(t值分别为2.516和2.325,均P＜0.05).结论 支气管哮喘患儿外周血T、B淋巴细胞明显异常高表达,可作为支气管哮喘轻重程度及治疗效果的评价指标.

Clinical significance of abnormal expressions of T and B lymphocytes in children with bronchial asthma

Objective To investigate the clinical significance of abnormal expressions of T and B lymphocytes in children with bronchial asthma.Methods Altogether 198 children with bronchial asthma treated in Ya' an People' s Hospital from January to October in 2016 were selected as study objects (asthma group),and healthy children receiving physical examination at the same time were randomly selected as control group according to 1:1 matching.In asthma group there were 107 cases in acute stage and 91 cases in remission stage,and 198 children were in the control group.T lymphocyte (CD3,CD3 + CD4 +,CD3 + CD8 + and CD4 +/CD8 +) and B lymphocyte (CD19 + CD23 +) in peripheral blood of children in acute stage and in remission stage and of children in the control group were tested,and relative indexes were compared.Results Levels of CD3 + CD4 + and CD19 + CD23 + of cases in acute stage were significantly higher than those in remission stage (t value was 2.479 and 2.341,respectively,both P ＜ 0.05) and those in the control group (t value was 2.421 and 2.524,respectively,both P ＜ 0.05).Level of CD4 +/CD8 + of cases in acute stage was significantly higher than that of cases in remission stage and in the control group,and the differences had statistic significance (t value was 2.516 and 2.325,respectively,both P ＜ 0.05).Conclusion Expressions of T and B lymphocytes in peripheral blood of children with bronchial asthma are obviously highexpressed,which can be used as an index to evaluate the severity and therapeutic effect of bronchial asthma.