围生期常用治疗对新生儿神经发育的影响

新生儿大脑处于不断发育成熟的过程中,围生期的各种干预治疗措施都会直接或间接地影响脑发育过程,糖皮质激素、非甾体类抗炎药、硫酸镁、亚低温治疗、枸橼酸咖啡因、肺表面活性物质、一氧化氮、促红细胞生成素等是围生期的常见药物及治疗,与新生儿的神经发育预后有着密切的关系.该文综述围生期常用治疗是否会直接或间接地对新生儿的神经发育产生不利影响.

Impact of common treatments given in the perinatal period on the neurodevelopment

The brain of neonates is growing and developing rapidly in perinatal period.Treatments in this period can have a direct or indirect effect on the developing brain.Steroids,indomethacin,magnesium sulphate,hypothermia,caffeine citrate,exogenous surfactant,nitric oxide,erythropoietin are common treatments administered during perinatal period.All those treatments are closely related to neurodevelopmental outcomes.We review these treatments on the developing brain.