骨髓增生异常综合征并发自身免疫性疾病的临床观察

目的：探讨骨髓增生异常综合征（MDS）与自身免疫性疾病的相互关系。方法：对117例MDS患者的临床资料进行分析并随访观察。结果：117例MDS患者中19例并发自身免疫性疾病，占16．2％；MDS并发自身免疫性疾病以类风湿关节炎（31．6％），溃疡性结肠炎（26．3％），常见；；MDS并发身自免疫性疾病者较无免疫性疾病者其转白率并不增加，但中位生存期缩短：结论：自身免疫性疾病是MDS预后不良的因素。MDS与自身免疫性疾病可能具有一定的内在关联。

The relationship between myelodysplastic syndromes and autoimmune disorders

Objective To explore the relationship between the myelodysplastic syndromes(MDS) and autoimmune disorders(AID). Methods The clinical data of 117 MDS patients were reviewed. Results Nineteen (16 2%)of 117 MDS patients had AIDs. The commonest AID associated with MDS was rheumatoid arthritis(31 6%)and ulcerative colitis(26.3%). Compared with that in MDS patients without autoimmune disorders, the leukemic transformation rate was not increased in the MDS/AID but the median survival time was shorter in MDS/AID patients. Conclusion MDS patients associated with autoimmune disorders may be an unfavorable factor for their prognosis.