Assessment of the drug level in bronchial secretion with patient's noncompliance and oral dosage forms with controlled release

The drug level was calculated in the plasma, the lung tissue and bronchial secretion using ciprofloxacin as the drug with erosion-controlled dosage forms. A numerical model was built and tested for this calculation. It takes into account the following stages: the kinetics of drug release along the gastrointestinal tract time, the absorption into and elimination out of the plasma, the diffusion through the lung tissue and convection into the bronchial secretion. Emphasis is placed upon the effect of patient's non-compliance on the drug levels, with intake omission, intake omission followed by double dosing, wrong frequency. Calculation with erosion-controlled dosage form with a long time of full erosion able to remain in the gastrointestinal over a period of time much longer than the usual gastrointestinal tract time shows the interest of bioadhesion.