| B7-H6在恶性肿瘤中的研究进展 |
| |
| 引用本文： | 刘学静(综述),徐燕颖(审校). B7-H6在恶性肿瘤中的研究进展[J]. 实用肿瘤学杂志, 2021, 35(1): 46-49. DOI: 10.11904/j.issn.1002-3070.2021.01.009 |
| |
| 作者姓名： | 刘学静(综述) 徐燕颖(审校) |
| |
| 作者单位： | 天津医科大学第二医院妇科(天津 300211) |
| |
| 基金项目： | 天津医科大学第二医院青年科研基金项目(编号:2018ydey16)。 |
| |
| 摘 要： | B7-H6是新近发现的免疫球蛋白超家族成员,是NK细胞表面活化性受体NKP30的膜结合配体.B7-H6较特异地表达于多种肿瘤组织,并且其表达水平与多种临床病理参数及预后显著相关.细胞表面B7-H6胞外域脱落后形成可溶性B7-H6,下调NKP30介导的NK细胞毒性及细胞因子的分泌.研究发现B7-H6通过蛋白酶抑制剂、My...
|
| 关 键 词： | B7-H6 sB7-H6 NKP30 肿瘤免疫 免疫治疗 |
Research progress of B7-H6 in malignant tumors |
| |
| LIU Xuejing,XU Yanying. Research progress of B7-H6 in malignant tumors[J]. Journal of Practical Oncology, 2021, 35(1): 46-49. DOI: 10.11904/j.issn.1002-3070.2021.01.009 |
| |
| Authors: | LIU Xuejing XU Yanying |
| |
| Affiliation: | Department of Gynecology,The Second Hospital of Tianjin Medical University,Tianjin 300211,China |
| |
| Abstract: | B7-H6,a newly discovered member of the immunoglobulin superfamily,is the membrane-binding ligand of NKP30,which is an activated receptor of the NK cell surface.B7-H6 is specifically expressed in various tumor tissues,and its expression is significantly correlated with various clinicopathological parameters and prognosis.The tumor cell ectodomain shedding of B7-H6 forms soluble B7-H6(sB7-H6),which down-regulates NKp30-mediated NK cell cytotoxicity and cytokine secretion.Studies have found that B7-H6 promotes tumorigenesis via protease inhibitors,Myc,abnormal immune response,proliferation,and anti-apoptosis.At present,the intervention therapy of the B7-H6 gene is a new tumor treatment strategy,and related immunotherapy is being explored.In summary,B7-H6 has been proved to be a potential biomarker and valuable therapeutic target for the diagnosis,treatment,prognostic evaluation of cancer. |
| |
| Keywords: | B7-H6 sB7-H6 NKP30 Tumor immunity Immunotherapy |
| 本文献已被 维普 等数据库收录！ |
| 点击此处可从《实用肿瘤学杂志》浏览原始摘要信息 |
|
点击此处可从《实用肿瘤学杂志》下载免费的PDF全文 |
|
