头颈部鳞状细胞癌转移机制及其影响因素研究进展

头颈部鳞状细胞癌(Head and neck squamous cell carcinoma,HNSCC)是一种主要来源于上呼吸道、消化道的非角化上皮癌性增生的恶性肿瘤.癌症转移为HNSCC患者预后差及病死率高的常见原因,HNSCC转移机制近年来成为众多学者关注与研究的热点之一.HNSCC的转移常常为癌细胞经上皮间质转...

Research progress of metastatic mechanism and influencing factors of head and neck squamous cell carcinoma

Head and neck squamous cell carcinoma(HNSCC)is a malignant neoplasm of non-keratotic epithelial hyperplasia mainly derived from the upper respiratory tract and digestive tract.Cancer metastasis is a common cause of poor prognosis and high mortality in HNSCC patients.The mechanism of HNSCC metastasis has become one of hotspots for many scholars in recent years.The metastasis of HNSCC is often the ability of cancer cells to acquire invasion and migration through the process of epithelial to mesenchymal transition(EMT).Cancer cells grow pseudopodia that can degrade the basement membrane and extracellular matrix(ECM),and jointly promote the production of HNSCC metastatic cancer.A variety of factors affect the HNSCC cancer metastasis,such as the hypoxic environment in which cancer cells are located,the glycolytic pathway of cancer cells,and the down-regulating expression of some tumor-related cells and neural precursor cells 9(expressed developmentally down-regulated 9,NEDD9)in which can promote the EMT process of HNSCC cancer cells and the generation of pseudopods,and promote cancer cells to leave the original site and transfer to blood vessels or lymphatic vessels.This article will make a systematic review for the transfer mechanism of HNSCC and its influencing factors.