| 脉平片药效学研究 |
| |
| 引用本文： | 沈敏,周敏,石小鹏,赵高潮,赵治国. 脉平片药效学研究[J]. 中国中医药信息杂志, 2009, 16(2): 43-44 |
| |
| 作者姓名： | 沈敏 周敏 石小鹏 赵高潮 赵治国 |
| |
| 作者单位： | 中国人民解放军第四军医大学西京医院药剂科,陕西,西安,710032 |
| |
| 摘 要： | 目的观察脉平片抗血栓、降脂、耐缺氧的药理作用。方法通过测定脉平片对实验性大鼠血栓模型血栓形成时间的影响，观察其抗血栓作用；建立大鼠高脂血症病理模型，观察脉平片的降脂作用；通过小鼠耐缺氧实验，观察脉平片的耐缺氧作用。结果脉平片3个剂量组均能够延长小鼠凝血时间，明显延长血浆凝血酶原时间、凝血酶原消耗时间及白陶土部分凝血活酶时间；脉平片高剂量组能够明显降低血清总胆固醇及三酰甘油含量，提高高密度脂蛋白胆固醇含量；脉平片3个剂量组常压下均能够提高小鼠低氧条件下的生存能力。结论脉平片有较好的抗凝、降脂及耐缺氧作用。
|
| 关 键 词： | 脉平片 抗血栓 降脂 耐缺氧 动物模型 |
Pharmacodynamics Research of Maiping Tablets |
| |
| Affiliation: | SHEN Min, ZHOU Min, SHI Xiao-peng, et al (Pharmacy Department, Xijing Hospital, The Forth Military Medical University of PLA, Xi＇an 710032, China) |
| |
| Abstract: | Objective To observe the pharmacological function about anti-clotting, lipid-reducing and anti-hypoxia of Maiping Tablets. Methods The experimental thrombus model of rats was made to observing anti-clotting function of Maiping Tablets. The high blood lipid syndrome model of rats was made to observing lipid-lowering function of Maiping Tablets. The mice anti-hypoxia experiment was taken to observing the function of hypoxia tolerance. Results Maiping Tablets could prolong dotting time, significantly decrease serum total and low-density lipoprotein cholesterol, increase high-density lipoprotein cholesterol, and increase the viability of laboratory mice under ordinary pressure. Conclusion Maiping Tablets has good effect of anticoagulation, lipid-reducing and anti-hypoxia. |
| |
| Keywords: | MaipingTablets anti-clotting lipid-loweringing anti-hypoxia animal model |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
