| 多肽、蛋白质药物的聚乳酸及其共聚物微球研究进展 |
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| 引用本文： | 刘玲,袁勤生. 多肽、蛋白质药物的聚乳酸及其共聚物微球研究进展[J]. 中国医药工业杂志, 2003, 34(3): 146-151 |
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| 作者姓名： | 刘玲 袁勤生 |
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| 作者单位： | 华东理工大学生物反应器工程国家重点实验室,上海,200237 |
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| 摘 要： | 综述了以可生物降解的合成高分子材料-聚乳酸及其共聚物为载体的多肽，蛋白质药物微球的制备方法和影响因素。讨论了蛋白质在制备和释放过程中的稳定性。
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| 关 键 词： | 聚乳酸及其共聚物 多肽和蛋白质药物 微球 蛋白质稳定性 |
| 文章编号： | 1001-8255(2003)03-0146-06 |
| 修稿时间： | 2001-12-04 |
Research Progress of Biodegradable Microspheres of Peptides and Proteins Encapsulated within Poly(lactic acid)and co-Polymers |
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| LIU Ling,YUAN Qin Sheng. Research Progress of Biodegradable Microspheres of Peptides and Proteins Encapsulated within Poly(lactic acid)and co-Polymers[J]. , 2003, 34(3): 146-151 |
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| Authors: | LIU Ling YUAN Qin Sheng |
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| Abstract: | The preparation methods of biodegradable PLA/PLGA therapeutic peptides or proteins microspheres and the critical factors involved were discussed, as well as the protein stability during the process and the release. |
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| Keywords: | PLA PLGA therapeutic peptides and proteins microsphere protein stability |
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