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Pseudomonas Aeruginosa Allergy in Cystic Fibrosis
Authors:P. Stahl,Skov ,S. Norn,,P. O. Schiø  tz,,H. Permin, N. Hø  iby
Affiliation:Department of Pharmacology, University of Copenhagen, Statens Seruminstitute's Departments of Clinical Microbiology at Hvidovre Hospital and at Rigshospitalet, and Laboratory of Immunology, University Clinic for Infectious Diseases, and Pediatric Department TG, Rigshospitalet, Copenhagen, Denmark
Abstract:Basophil histamine release by P. aeruginosa standard antigen was examined in cystic fibrosis patients chronically infected with mucoid P. aeruginosa (CF +P) and with pronounced antibody response against these bacteria, and in patients without P. aeruginosa infection (CF +P). All the patients showed eosinophil counts and total IgE, which did not differ significantly from that of normal persons. In the absence of patient's sera, histamine release was only found in two patients in the CF +P group, indicating that type I allergy to P. aeruginosa is not predominating in cystic fibrosis. In the presence of patients' sere significantly more of the CF+P patients responded to P. aeruginosa with histamine release compared with the CF-P patients. The response was lost by complement inactivation and regained by reconstitution of the complement activity. The involvement of a type III-mediated complement-dependent histamine release is therefore suggested in the pathogenesis of lung damage in cystic fibrosis.
Keywords:allergic type I reaction    allergic type III reaction    complement    cystic fibrosis    histamine release    Pseudomonas aeruginosa
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