三种疗法对防止激光术后尖锐湿疣复发的疗效观察

目的 比较咪喹莫特乳膏局部外用、干扰素局部封闭、肌肉注射卡介菌多糖对激光术后尖锐湿疣(Condyloma acuminatum,CA)复发的疗效.方法 对2002年1月至2007年6月门诊就诊的175例CA患者进行回顾性分析,共分A、B、C、D组,均行激光手术去除疣体,A组50例外用咪喹莫特乳膏;B组50例局部封闭干扰素100万单位;C组45例肌注卡介菌多糖核酸;D组30例局部不用任何药物(对照组).结果 A组复发率12.00%,B组复发率16.00%,C组复发率71.11%,D组复发率73.33%.A组局部外用咪喹莫特乳膏与B组局部封闭干扰素预防尖锐湿疣复发有较好疗效(P＜0.01),二者之间(P＞0.05)无统计学意义.结论 咪喹莫特软膏局部外用和干扰素皮损内注射有效防止尖锐湿疣复发.

Efficacy of Three Treatments after CO2 Laser Excision on Condyloma Acuminatum

Objective To compare the efficacy of three different treatments on condyloma acuminatum recurrence.Methods Total 175 cases of outpatient condyloma acuminatum (Jan,2002-Jun,2007) received surgical excision with CO2 laser with one of the following adjunct remedies:Imiquimod ointment topical use,interferon alpha-2b intralesional injection, polysaccharide nucleic acid intramuscular injection and normal control (without any treatments).Results The recurrent rates of three remedies of Imiquimod ointment,interferon alpha, and polysaccharide nucleic acid and normal control were 12.00 %,16.00%,71.11 % and 73.33%,respectively.There were statistical difference between the two former remedies and polysaccharide nucleic acid or control group(P<0.01).However,there were not statistical difference between Imiquimod and interferon remedy(P>0.05). Conclusion Imiquimod ointment topical use and interferon intralesional injection may have prophylactic potential against recurrence of condyloma acuminatum.