| EGCG联合放疗治疗鼻咽癌裸鼠移植瘤模型 |
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| 引用本文： | 宁喜,倪菊芳,易世江. EGCG联合放疗治疗鼻咽癌裸鼠移植瘤模型[J]. 中国耳鼻咽喉头颈外科, 2011, 18(4): 200-203 |
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| 作者姓名： | 宁喜 倪菊芳 易世江 |
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| 作者单位： | 1. 江苏省盐城市第三人民医院耳鼻喉科;2. 桂林医学院附属医院耳鼻咽喉-头颈外科; |
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| 摘 要： | 目的 研究表没食子儿茶素没食子酸酯(epigallocatechin-3-gallate,EGCG)对鼻咽癌裸鼠移植瘤放疗的增敏效应及survivin和VEGF的表达及意义.方法 体外培养低分化鼻咽癌CNE-2细胞,接种于20只雄性裸鼠皮下,待肿瘤结节约4～6 mm时,随机分为生理盐水组、EGCG组(30 mg/kg)...
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| 关 键 词： | 儿茶素 鼻咽肿瘤 肿瘤种植 肿瘤细胞，培养的 凋亡抑制蛋白类 放疗增敏 |
| 收稿时间： | 2010-08-23 |
EGCG combined with radiation in the treatment of xenotransplanted nasopharyngeal carcinoma in nude mice |
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| NING Xi,NI Jufang,YI Shijiang Corresponding author: YI Shijiang. EGCG combined with radiation in the treatment of xenotransplanted nasopharyngeal carcinoma in nude mice[J]. Chinese Archives of Otolaryngology-Head and Neck Surgery, 2011, 18(4): 200-203 |
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| Authors: | NING Xi NI Jufang YI Shijiang Corresponding author: YI Shijiang |
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| Affiliation: | 1 Department of Otolaryngology,the Third People＇s Hospital of Yancheng,Yancheng,Jiangsu,224001,China;2 Department of Otolaryngology,the Af？liated Hospital of Guilin Medical College,Guilin,Guangxi,541001,China) Corresponding author： YI Shijiang(Email： yishijiang@yahoo.cn) |
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| Abstract: | OBJECTIVE To study the expression and significance of survivin and VEGF mRNA in xenotransplanted nasopharyngeal carcinoma after treated by EGCG combined with radiation in nude mice.METHODS Nasopharyngeal carcinoma CNE-2 cells were cultured in vitro and injected subcutaneously into twenty male nude mice to establish human tumor xenografts.When the diameter of the tumors reached 4 to 6 mm,the twenty nude mice were randomly divided into four groups: control group,EGCG group,radiation group,EGCG combined with r... |
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| Keywords: | Catechin Nasopharyngeal Neoplasms Neoplasm Seeding Tumor Cells Cultured Inhibitor of Apoptosis Proteins radiosensitivity |
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