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| 肝素对急性肺损伤大鼠不同时期凝血功能影响 | |
| 引用本文： | 陈龙,王瑞兰,张君,许艳岚,朱宏. 肝素对急性肺损伤大鼠不同时期凝血功能影响[J]. 中华肺部疾病杂志(电子版), 2011, 4(2): 106-109. DOI: 10.3877/cma.j.issn.1674-6902.2011.02.010 |
| 作者姓名： | 陈龙 王瑞兰 张君 许艳岚 朱宏 |
| 作者单位： | 上海交通大学附属第一人民医院,上海,201620 |
| 摘 要： | 目的探讨肝素在急性肺损伤／急性呼吸窘迫综合征（acutelunginjur#acuterespiratorydisttesssyndrome，ALI／ARDS）不同时期对凝血功能的影响。方法将30只清洁级雄性SD大鼠随机分成5组，每组6只，空白组（A组）＋造模组（B组）＋0h肝素治疗组（C组）＋2h肝素治疗组（D组）＋4h肝素治疗组（E组），肺损伤大鼠用尾静脉注射油酸0．2mL／kg联合4h后内毒素（LPS）（4mg／mL）5mg／kg腹腔注射，6h后处死动物并采血行凝血功能检测。结果C组及D组镜下病理表现较B组及E组：肺泡腔内炎性细胞渗出较少，出血较少。血浆纤维蛋白原（fibrinogen，FIB）各组间显著差异有统计学意义（P〈0．01），B组和E组FIB显著下降，与A组比较差异有统计学意义（P〈0．05）。C组与D组FIB与A组比较无明显下降，差异无统计学意义。A组、C组以及D组与B组比较有显著的差异，差异有统计学意义（P〈0．05），B组及E组与A组比较有显著差异，差异有统计学意义（P〈0．05）。结论较早使用肝素治疗对于改善FIB消耗有作用，可以减少肺组织炎症渗出，减轻肺组织充血。 |
| 关 键 词： | 急性肺损伤／急性呼吸窘迫综合征 肝素 抗凝 凝血功能 油酸 |
Heparin on coagulation function in rats with acute lung injury in different stages |
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| CHEN Long,WANG Rui-lan,ZHANG Jun,XU Yan-lan,ZHU Hong. Heparin on coagulation function in rats with acute lung injury in different stages[J]. Chinese Journal of lung Disease（Electronic Edition）, 2011, 4(2): 106-109. DOI: 10.3877/cma.j.issn.1674-6902.2011.02.010 | |
| Authors: | CHEN Long WANG Rui-lan ZHANG Jun XU Yan-lan ZHU Hong |
| Affiliation: | CHEN Long,WANG Rui-lan,ZHANG Jun,XU Yan-lan,ZHU Hong(Shanghai First People's Hospital,Shanghai Jiao Tong University,Shanghai,200080,China) |
| Abstract: | Objective This study was to further study the effect of heparin on coagulation in rats with acute lung injury/acute respiratory distress syndrome(ALI/ARDS) in different stages.Method 30 rats were randomly divided into five groups (n=6):normal control group (group A),model group (group B),0 h heparin treatment group (group C),2 h heparin treatment group (group D) and 4 h heparin treatment group (group E).Rat ALI model was established by intravenous injection with oleic acid (0.2mL/kg) and after 4 h abdomen i... |
| Keywords: | Acute lung injury/acute respiratory distress syndrome Heparin Anticoagulation Coagulation function Oleic acid |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |