| 蛋白多肽类药物纳米粒口服给药系统的研究进展 |
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| 引用本文： | 崔福德,石凯,寸冬梅. 蛋白多肽类药物纳米粒口服给药系统的研究进展[J]. 沈阳药科大学学报, 2010, 27(12): 946-951 |
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| 作者姓名： | 崔福德 石凯 寸冬梅 |
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| 作者单位： | 沈阳药科大学 药学院，辽宁 沈阳 110016 |
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| 摘 要： | 目的综述近年来纳米粒作为蛋白质多肽类药物口服传递系统方面的研究现状和进展。方法分析有关文献资料,从纳米粒给药系统的载体材料、口服药效等方面进行了概述。结果纳米粒给药系统可提高蛋白质和多肽类药物的口服吸收效率,提高此类药物的生物利用度。结论纳米粒给药系统在口服传递蛋白质和多肽类药物方面有着广阔的研究和应用前景。
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| 关 键 词： | 多肽 蛋白质 纳米粒 口服给药 |
| 收稿时间： | 2010-09-08 |
Advances in nanoparticles as oral delivery systems for proteins and peptides |
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| CUI Fu-de,SHI Kai,CUN Dong-mei. Advances in nanoparticles as oral delivery systems for proteins and peptides[J]. Journal of Shenyang Pharmaceutical University, 2010, 27(12): 946-951 |
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| Authors: | CUI Fu-de SHI Kai CUN Dong-mei |
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| Affiliation: | School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China |
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| Abstract: | Objective To review the recent advances in nanoparticles as oral delivery systems for proteins and peptides.Methods Based on related literature,the paper summarizes the carriers and efficacy of nanoparticles as oral delivery systems for proteins and peptides.Results Nanoparticle systems can improve the oral bioavailability of biopharmaceuticals such as proteins and peptides.Conclusions Nanoparticles systems enjoy a promising future in oral delivery of proteins and peptides. |
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| Keywords: | peptide protein nanoparticles oral delivery |
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