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Endoscopic appearance of the colon and small intestine of a patient with hemorrhagic enteric graft-vs.-host disease |
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| Authors: | Dr. Hiroshi Saito M.D. Kazuo Oshimi M.D. Kou Nagasako M.D. Kurato Yashiro M.D. Toshio Tanaka M.D. Chisato Toyoda M.D. Hideaki Mizoguchi M.D. |
| Affiliation: | (1) Division of Hematology, Department of Medicine, Tokyo Women's Medical College, 8-1 Kawada-cho, Shinjuku-ku, 162 Tokyo, Japan;(2) Division of Gastroenterology, Department of Medicine, Tokyo Women's Medical College, Tokyo, Japan;(3) Division of Pathology, Department of Medicine, Tokyo Women's Medical College, Tokyo, Japan |
| Abstract: | Endoscopic appearance of the gastrointestinal tract of a patient with severe hemorrhagic enteric graft-vs.-host disease (GVHD) is presented. A 29-year-old man with chronic myelogenous leukemia suffered from severe enteric GVHD after allogeneic bone marrow transplantation. Endoscopy showed hemorrhagic ulceration of the upper jejunum, terminal ileum, and colon at the onset of melena. Sections of biopsies were compatible with acute GVHD. Repeat endoscopy showed gradual healing of the lesions after steroid pulse and antilymphocyte globulin therapy, but the patient died of cytomegalovirus pneumonitis 14 months later. Autopsy revealed submucosal fibrosis of the small intestine and colon. |
| Keywords: | Graft-vs.-host disease Colitis Colonoscopy Chronic myelogenous leukemia |
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