细胞粘附分子变异体在结直肠癌中的表达及预后

目的探讨细胞粘附分子变异体(CD44v6)在结直肠癌中的表达及与患者预后的关系。方法应用SP免疫组织化学法检测CD44v6蛋白在120例结直肠癌中的表达。结果CD44v6在结直肠癌中的阳性表达率为31.7%(38/120);CD44v6的阳性表达与淋巴结转移和Dukes’分期有关(P<0.05);有淋巴结转移组CD44v6的阳性表达率比无淋巴结转移组高;且随着Dukes’分期的加深,CD44v6的阳性表达率逐渐增高;CD44v6的表达与结直肠癌患者的生存时间有关(P<0.01),CD44v6阳性表达的患者预后较差。结论CD44v6的表达与结直肠癌淋巴结转移、Dukes’分期和患者生存时间有关。CD44v6可能为影响结直肠癌患者预后的一个重要因素。

Expression of CD44v6 protein associated with prognosis in colorectal carcinoma

Objective To investigate the relationship between expression of CD44v6 and prognosis of colorectal carcinoma(CRC).Methods The expression of CD44v6 in 120 CRC cases was detected by Streptavidin-Peroxidase immunohistochemical technique.Results The positive expression rate of CD44v6 in CRC was 31.7%(38/120).The positive expression of CD44v6 in CRC was significantly associated with lymph nodes metastasis and Dukes' stage(P<0.05).The positive expression rate of CD44v6 in CRC with lymph nodes metastasis was significantly higher than that without lymph nodes metastasis;the positive expression rate of CD44v6 was gradually increasing when Dukes' stage deeping.CD44v6 expression was correlated to survival time of CRC cases(P<0.01).Conclusion CD44v6 expression in CRC is associated with Dukes' stage,lymph nodes metastasis and survival time of CRC cases.CD44v6 is a prognostic factor of CRC probably.