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In vitro activities of pentamidine,pyrimethamine, trimethoprim,and sulfonamides against Aspergillus species
Authors:Afeltra Javier,Meis Jacques F G M,Vitale Roxana G,Mouton Johan W,Verweij Paul E  Eurofung Network
Affiliation:Department of Medical Microbiology, University Medical Center Nijmegen, The Netherlands.
Abstract:The susceptibilities of 70 strains of Aspergillus species were tested against seven different sulfa drugs and pentamidine by a microdilution method with RPMI 1640 and yeast nitrogen base media. Sulfamethoxazole, sulfadiazine, and pentamidine were active in vitro. The MICs obtained with RPMI 1640 were significantly higher than those with yeast nitrogen base. More studies are needed to further elucidate the action of these drugs.
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