孤立性纤维性肿瘤16例临床病理分析

[目的]分析孤立性纤维性肿瘤的临床表现,病理形态学及免疫组化的特点,以提高对其临床病理特点的认识。[方法]收集孤立性纤维肿瘤患者16例,采用光镜和免疫组化染色法进行分析。[结果]本组16例患者,男性7例,女性9例,共发生在9个部位,临床主要表现为局部肿块及引起的压迫症状。主要病理改变:肿瘤最大14cm×9cm×5cm,最小的为2cm×2cm×1cm。镜下:肿瘤细胞为卵圆,短至长梭形细胞,呈束状,车辐状或散乱排列,细胞疏密不均,肿瘤细胞间有粗大的胶原纤维束。免疫组化结果:Vimitin和CD34阳性率100(16/16),CD99阳性率87,SMA阳性率25(4/16),EMA阳性率19(3/16),S-100阳性率13(2/16)。[结论]SFT可发生全身各部位,需与其他多种梭形细胞肿瘤进行鉴别诊断,诊断主要靠形态学及免疫组织化学。大部分SFT为良性,部分可复发或发生远处转移,手术切除为主要治疗手段,术后的定期随访是必要的。

CLINICAL PATHOLOGICAL ANALYSIS OF 16 CASES OF SOLITARY FIBROUS TUMORS

[Objective]To explore the clinical morphology and immunohistochemical features of Solitary Fibrous Tumor(SFT).[Methods]Used light microscopy and immunohistochemical staining to analyze 16 cases of SFT.[Results]The 7 male and 9 female patients between 20 and 68 years old(mean 45)were analyzed.SFTS occurred in 9 sites and the main clinical manifestations were local mass and pressure symptom.Histologically,the tumors composed of hypoand hyper cellar areas,Keloid-like Collagen bundles in the stroma,thin-walled ...