| 高效液相色谱-电喷雾质谱联用分析红参与五味子配伍机制 |
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| 引用本文： | 张宪臣,张旭,陈光,刘志强,刘淑莹. 高效液相色谱-电喷雾质谱联用分析红参与五味子配伍机制[J]. 医学教育探索, 2007, 0(1): 41-43 |
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| 作者姓名： | 张宪臣 张旭 陈光 刘志强 刘淑莹 |
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| 作者单位： | 中国科学院长春应用化学研究所，中国科学院长春应用化学研究所，吉林农业大学生物技术学院，中国科学院长春应用化学研究所，中国科学院长春应用化学研究所 吉林长春130022中山市出入境检验检疫局，广东中山528400，吉林长春130022，吉林长春130118，吉林长春130022，吉林长春130022 |
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| 基金项目： | 国家自然科学基金;中国科学院知识创新工程项目;吉林省科技厅科技发展基金;长春市科学技术局科技计划项目 |
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| 摘 要： | 目的研究红参与五味子配伍过程中人参皂苷类化合物的变化机制。方法采用高效液相色谱-电喷雾质谱联用技术对红参与五味子5种配伍比例水煎液中人参皂苷的变化进行了研究。结果在五味子量较少的条件下,红参与五味子水煎液中人参皂苷Rg1、Re、Rb1、Rc、Rb2、Rd发生水解。随着五味子量的增加,人参皂苷Ro的量发生减少,而人参微量次级皂苷F2的量显著增加。结论红参与五味子配伍后产生的特殊药效可能与两者配伍过程中人参皂苷F2的量显著增加有关。
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| 关 键 词： | 红参 五味子 人参皂苷 高效液相色谱-电喷雾质谱 |
Analysis of compatibility mechanism of Radix Ginseng Rubra with Fructus Schisandrae Chinensis by HPLC-ESI-MS |
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| ZHANG Xian-chen,ZHANG Xu,CHEN Guang,LIU Zhi-qiang,LIU Shu-ying. Analysis of compatibility mechanism of Radix Ginseng Rubra with Fructus Schisandrae Chinensis by HPLC-ESI-MS[J]. Researches in Medical Education, 2007, 0(1): 41-43 |
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| Authors: | ZHANG Xian-chen ZHANG Xu CHEN Guang LIU Zhi-qiang LIU Shu-ying |
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| Affiliation: | 1. Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; 2. Zhongshan Entry-Exit Inspection and Quarantine Bureau, Zhongshan 528400, China; 3. College of Biotechnology, Jilin Agriculture University, Changchun 130118, China |
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| Abstract: | Objective To study the reation mechanism of ginsenosides in compatibility of Radix Ginseng Rubra with Fructus Schisandrae Chinensis.Methods Five different compound decoctions of Radix Ginseng Rubra with Fructus Schisandrae Chinensis were analyzed by HPLC-ESI-MS.Results Ginsenoside Rg_1,Re,Rb_1,Rc,Rb_2,and Rd in water decoction of Radix Ginseng Rubra with Fructus Schisandrae Chinensis were hydrolyzed at a little content of Fructus Schisandrae Chinensis added.With the increasing content of Fructus Schisandrae Chinensis,the content of ginsenoside Ro decreased but the content of ginsenoside F_2 increased significantly.Conclusion The obvious increasing of ginsenoside F_2 could be responsible for the special effect of compatibility of Radix Ginseng Rubra with Fructus Schisandrae Chinensis. |
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| Keywords: | Radix Ginseng Rubra Fructus Schisandrae Chinensis ginsenoside high performance liquid chromatography-electrospray ionization mass spectrometry (HPLC-ESI-MS) |
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