| 法舒地尔治疗急性心肌梗死时血清IL-6、TNF-α、NO的变化及疗效评价 |
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| 引用本文： | 代莉,王慧智,田倩,王洪浩,方沛钰.法舒地尔治疗急性心肌梗死时血清IL-6、TNF-α、NO的变化及疗效评价[J].现代预防医学,2011,38(12):2434-2435,2439. |
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| 作者姓名： | 代莉 王慧智 田倩 王洪浩 方沛钰 |
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| 作者单位： | 贵州省贵阳市第二人民医院心内科,贵阳,550000 |
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| 摘 要： | 目的]通过测定血清IL-6、TNF-α、NO的变化水平情况,观察法舒地尔对急性心肌梗死(AMI)的治疗作用,探讨盐酸法舒地尔在心肌梗死炎症治疗方面的可能作用并评价其临床疗效。方法]选择未能接受溶栓或急诊PCI治疗的急性心肌梗死患者共70例,随机分为法舒地尔组(治疗组)和对照组,两组均予硝酸甘油、阿司匹林、氯吡格雷及调脂等常规治疗,治疗组在对照组基础上加用盐酸法舒地尔(天津红日药业股份有限公司生产)30mg加入5葡萄糖注射液或生理盐水100ml静脉滴注,每日2次,连续治疗14d。结果]在常规治疗基础上加用法舒地尔治疗急性心肌梗死对心功能的改善较对照组有效,血清炎症因子浓度水平与心肌梗死后心功能状态呈负相关。结论]法舒地尔能有效保护急性心肌梗死后的存活心肌细胞,抑制心肌梗死急性期血清炎症因子峰值,从而减少炎症因子对心肌细胞的损害,并有效改善心功能,具有肯定的临床疗效。
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| 关 键 词： | 法舒地尔 急性心肌梗塞 Rho激酶 |
CURATIVE EFFECT ASSESSMENT AND THE CHANGE OF IL-6, TNF AND NO IN SERUM OF FASUDIL HYDROCHLORIDE INJECTION IN THE TREATMENT OF ACUTE MYOCAR-DIAL INFARCTION |
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| DAI Li,WANG Hui-zhi,TIAN Qian,et al..CURATIVE EFFECT ASSESSMENT AND THE CHANGE OF IL-6, TNF AND NO IN SERUM OF FASUDIL HYDROCHLORIDE INJECTION IN THE TREATMENT OF ACUTE MYOCAR-DIAL INFARCTION[J].Modern Preventive Medicine,2011,38(12):2434-2435,2439. |
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| Authors: | DAI Li WANG Hui-zhi TIAN Qian |
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| Institution: | DAI Li,WANG Hui-zhi,TIAN Qian,et al.(Deptartment of Cardiology,The Second People's Hospital of Guiyang,Guiyang 550000,China) |
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| Abstract: | Objective]To observe the curative effect of Fasudil Hydrochloride Injection in the treatment of acute myocardial infarction(AMI)by determine the change of IL-6,TNF and NO in serum,and explore the possible effect and assess the clinical effects of Fasudil Hydrochloride Injection in the treatment of acute myocardial infarction(AMI).Methods]70 patients of acute myocardial infarction,include which not accept thrombolytic therapy or accept emergency treatment of PCI,were randomly divided into curative group an... |
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| Keywords: | Fasudil Hydrochloride Injection Acute myocardial infarction Rho kinase |
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