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| 消银解毒饮对金黄色葡萄球菌肠毒素B型诱导小鼠血清白细胞介素-8水平的影响 | |
| 引用本文： | 刘铭,瞿幸,周冠芬,钱家骏,张建中.消银解毒饮对金黄色葡萄球菌肠毒素B型诱导小鼠血清白细胞介素-8水平的影响[J].中国中西医结合杂志,2001,21(10). |
| 作者姓名： | 刘铭 瞿幸 周冠芬 钱家骏 张建中 |
| 作者单位： | 1. 北京中医药大学 2. 北京中医药大学东直门医院 3. 北京大学人民医院 |
| 基金项目： | 国家中医药管理局重点课题科研基金课题资助 (No.95A2 4 1 5) |
| 摘 要： | 目的 :研究消银解毒饮治疗银屑病的机理。方法 :采用金黄色葡萄球菌肠毒素B型 (SEB) ,诱导小鼠血清IL 8异常升高 ,随后观察消银解毒饮与复方青黛胶囊对SEB诱导IL 8的拮抗作用。结果 :小鼠腹腔注射SEB 3～ 5h后血清IL 8水平达到高峰 ;消银解毒饮大小剂量组均能显著拮抗SEB的诱导作用 ,而大剂量组的作用尤为显著。结论 :消银解毒饮大、小剂量均能有效地拮抗SEB诱导IL 8的作用 ,结合超抗原理论 ,从细胞生物学水平阐发了消银解毒饮的清热凉血解毒功效。 |
| 关 键 词： | 消银解毒饮 金黄色葡萄球菌肠毒素B型 白细胞介素8 |
Effect of Xiaoyin Jiedu Yin on Staphylococcus Aureus Enterotoxin B Induced Serum Interleukin 8 in Mice |
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| Authors: | LIU Ming QU Xing ZHOU Guan fen Beijing University of TCM Beijing |
| Abstract: | To explore the therapeutic mechanism of Xiaoyin Jiedu Yin (XYJDY) in treating psoriasis. Methods: Abnormal elevation of interleukin 8 (IL 8) level in mice was induced by Staphylococcus aureus enterotoxin B (SEB), then the antagonizing effects of XYJDY and Composite Qingdai Capsule were observed. Results: Serum IL 8 level arose and reached the peak 3-5 hrs after SEB induction. XYJDY could antagonize the induction significantly, and the effect was more significant when large dosage was given. Conclusion: XYJDY, in either large or small dose, could effectively antagonize the SEB induction on IL 8. Applying with superantigen theory, this fact could be used to elucidate the mechanism of XYJDY in removing Heat, cooling blood and detoxifying at cell biologic level. |
| Keywords: | Xiaoyin Jiedu Yin Staphylococcus aureus enterotoxin B interleukin 8 |
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