| 乳腺增生病p53基因第8外显子突变及p53蛋白表达 |
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| 引用本文： | 杨举伦,蔡学敏,普苹,邹红,李涛,王力,蔡琳. 乳腺增生病p53基因第8外显子突变及p53蛋白表达[J]. 中国肿瘤临床, 2002, 29(6): 388-391 |
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| 作者姓名： | 杨举伦 蔡学敏 普苹 邹红 李涛 王力 蔡琳 |
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| 作者单位： | 1. 成都军区昆明总医院病理科,昆明市,650032
2. 昆明医学院附属第一医院病理科 |
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| 基金项目： | 本文课题受云南省自然科学基金资助(编号:97C096M) |
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| 摘 要： | 目的：探讨p53基因在乳腺癌发生早期的作用。方法：用免疫组化检测36例乳腺单纯增生，31例不典型增生，30例乳腺癌组织中p53蛋白表达，用PCR－RFLP检测p53基因第8外显子第278密码子突变。结果：乳腺单纯性增生，不典型增生和乳腺癌中p53蛋白表达率分别为0，22．6％，46．7％。p53基因第8外显子的突变率分别为0，3．2％，10．0％，均为杂合子突变。结论：乳腺癌不典型增生中存在p53蛋白表达和该基因第8外显子突变，该突变可能在乳腺增生病向乳腺癌进展过程中起一定作用。
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| 关 键 词： | 乳腺增生病 p53基因 p53蛋白 乳腺癌 基因突变 |
| 文章编号： | 1000-8179(2002)06-0388-04 |
| 修稿时间： | 2001-07-27 |
Mutations in Exon 8 of p53 gene and Expression of p53 Protein in Breast Hyperplasia |
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| Yang Julun Cai Xuemin Pu Ping et al. Mutations in Exon 8 of p53 gene and Expression of p53 Protein in Breast Hyperplasia[J]. Chinese Journal of Clinical Oncology, 2002, 29(6): 388-391 |
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| Authors: | Yang Julun Cai Xuemin Pu Ping et al |
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| Affiliation: | Yang Julun Cai Xuemin Pu Ping et al Department of Pathology,Kunming General Hospital of Chengdu Military Command,Kunming |
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| Abstract: | Objective:To investigate the role of p53gene in the early stages of human breast carcinogenesis.Methods:Thirty-six cases of epithelial hyperplasia of usual type,31cases of atypical hyperplasia and30cases of breast carcinoma were employed to detect the expression of p53protein immunohistochemically and exon8mutations of p53gene by polymerase chain re-action restrictive filament length polymorphism(PCR-RFLP).Results:p53protein was expressed in22.6%of breast atypical hyperplasia,46.7%of breast carcinomas and none of breast ususal type hyperplasia.Mutations in exon8of p53gene were found in3.2%of breast atypical hyper-plasia,10%of breast carcinomas and none of usual type hyperplasia.Conclusion:Expression of p53protein and exon8mutations of p53gene are involved in breast atypical hyperplasia which may play some biological role in the development form hyperplasia to breast cancer |
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| Keywords: | Breast cancer Breast hyperplasia p53gene Mutation p53protein |
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