Effects of H2-receptor antagonists on the central nervous system

Histamine functions as a neurotransmitter in the central nervous system (CNS), and H₂-receptor activation can modulate the activity of the CNS. H₂-receptor antagonists are known to penetrate the blood-brain barrier and to cause neuropsychiatric effects. It appears that interactions with CNS H₂-receptors may account for many of these effects, although receptor interactions unique to certain H₂-antagonists may also play a role.