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Imaging with second-harmonic radiation probes in living tissue |
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| Authors: | Grange Rachel Lanvin Thomas Hsieh Chia-Lung Pu Ye Psaltis Demetri |
| Affiliation: | 1Laboratory of Optics, School of Engineering, EPFL, Station 17, 1015 Lausanne, Switzerland;2Multiphoton Laboratory, Institute of Applied Physics, Friedrich Schiller University, Albert-Einstein-Str. 15, 07745 Jena, Germany;3Department of Electrical Engineering, California Institute of Technology, 1200 East California Boulevard, MC 136-93, Pasadena, California 91125, USA |
| Abstract: | We demonstrate that second-harmonic radiation imaging probes are efficient biomarkers for imaging in living tissue. We show that 100 nm and 300 nm BaTiO(3) nanoparticles used as contrast markers could be detected through 50 μm and 120 μm of mouse tail tissue in vitro or in vivo. Experimental results and Monte-Carlo simulations are in good agreement. |
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