| 联苯双酯片剂的溶出度方法研究 |
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| 引用本文： | 刘利群,白政忠,姜连阁,金涛. 联苯双酯片剂的溶出度方法研究[J]. 中国药品标准, 2012, 13(1): 41-44 |
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| 作者姓名： | 刘利群 白政忠 姜连阁 金涛 |
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| 作者单位： | 1. 黑龙江省食品药品检验检测所,哈尔滨,150001
2. 黑龙江大学,哈尔滨,150086 |
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| 摘 要： | 目的:建立联苯双酯片剂的溶出度测定方法.方法:方法采用桨法,以2.0％十二烷基硫酸钠溶液为溶出介质,转速75 r·min-1,取样时间60 min；采用HPLC法测定溶出量.结果:不同生产厂家的联苯双酯片剂的溶出度存在显著差异.结论:所建方法可为提高联苯双酯片剂质量标准,建立合理的溶出度方法提供依据.
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| 关 键 词： | 联苯双酯片 溶出度 |
Study of Method for Dissolution Test of Bifendate Tablets |
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| Liu Liqun,Bai Zhengzhong,Jiang liange and Jin Tao. Study of Method for Dissolution Test of Bifendate Tablets[J]. , 2012, 13(1): 41-44 |
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| Authors: | Liu Liqun Bai Zhengzhong Jiang liange Jin Tao |
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| Affiliation: | 2 ＊ (Heilongjiang Provincial Institute For Foodstuff＆ Drug Control , Harbin 150001 ; Heilongfiang University , Harbin 150086 ) |
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| Abstract: | Objective： To establish a method of dissolution test of bifendate tablets. Methods： The paddle method was used with 2.0% sodium dodecyl as dissolution medium at a rotate speed of 75 r · min-1, sampling time was 60 minutes. HPLC method was used to determine the content of bifendate. The dissolution of different brands of Bifendate tablets was investigated. Results： The results showed bifendate tablets from different manufactures are significant differences in dissolution. Conclusion： For bifendate tablets, the proposed method provides a basis for establishing a reasonnble dissolution test method and improving quanlity standards . |
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| Keywords: | bifendate tablets dissolution rate |
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