An allergic reaction following intrauterine insemination

Intrauterine insemination is a common procedure used for the treatment ofdifferent causes of infertility. Adverse reactions associated with thisprocedure are very rare and usually the procedure is well tolerated by thepatient. We report a case of an allergic reaction after intrauterineinsemination. The patient developed fever, difficulty breathing andwheezing in both lung fields. Although a low concentration of penicillin inthe medium was used, it caused a significant allergic reaction. Whenintrauterine insemination was performed in subsequent cycles with anantibiotic-free medium, no allergic reaction occurred, and the procedurewas well tolerated by the patient. A careful allergy history is essentialin patients pursuing infertility treatment where antibiotics are utilized.Patients who are known to be allergic to penicillin should have semenprepared by an antibiotic-free medium.