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| 白芨对大鼠创面愈合几个要素的影响 | |
| 引用本文： | 孙仁山,陈晓红,程天民,冉新泽,阎国和,粟永萍,刘荣卿. 白芨对大鼠创面愈合几个要素的影响[J]. 中国组织工程研究与临床康复, 2003, 7(29): 3927-3929 |
| 作者姓名： | 孙仁山 陈晓红 程天民 冉新泽 阎国和 粟永萍 刘荣卿 |
| 作者单位： | 1. 解放军第三军医大学,全军复合伤研究所,创伤、烧伤与复合伤国家重点实验室,重庆市,400038 2. 解放军第三军医大学,药理学教研室,重庆市,400038 |
| 基金项目： | 国家重点基础研究973项目(G1999054205)~~ |
| 摘 要： | 目的:研究白芨对大鼠创面愈合几个要素的影响,探讨其促进伤口愈合的机制。方法:大鼠麻醉后,在背部脊柱两侧1.5cm处切除两个直径约1.6cm的圆形,以随机数字表法选择其中一个创面局部涂抹白芨胶溶液;或在背部脊柱两侧1.5cm处各切开一约8cm长的全皮层切口,埋入聚乙烯醇(Polyvinylalcohol,PVA)海绵,随机数字表法选择一侧注入白芨胶溶液。结果:伤后3(或5),7,10,14,21d白芨治疗组创面残留面积百分率显著低于对照组,创面平均愈合时间提前2.5d,创面组织蛋白含量和羟脯氨酸含量也显著高于对照。伤后3,5,7d白芨组伤口巨噬细胞数量也显著提高。结论:白芨提高创面愈合的速度和愈合的质量,增加伤口巨噬细胞数量可能是其促愈合的重要机制之一。 |
| 关 键 词： | 白芨 伤口愈合 外用药 |
| 文章编号： | 1671-5926(2003)29-3927-03 |
| 修稿时间： | 2003-07-26 |
Some factors of Bletilla Striata in wound healing |
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| Ren Shan Sun,Xiao Hong Chen,Tian Min Cheng,Xin Ze Ran,Guo He Yan,Yong Ping Su,Rong Qing LiuRen Shan Sun,Xiao Hong Chen,Tian Min Cheng,Xin Ze Ran,Guo He Yan,Yong Ping Su,Rong Qing Liu,National Key Laboratory of Trauma,Burns and Combined Injury,Third Military Medical University. Some factors of Bletilla Striata in wound healing[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2003, 7(29): 3927-3929 | |
| Authors: | Ren Shan Sun Xiao Hong Chen Tian Min Cheng Xin Ze Ran Guo He Yan Yong Ping Su Rong Qing LiuRen Shan Sun Xiao Hong Chen Tian Min Cheng Xin Ze Ran Guo He Yan Yong Ping Su Rong Qing Liu National Key Laboratory of Trauma Burns Combined Injury Third Military Medical University |
| Affiliation: | Ren Shan Sun,Xiao Hong Chen,Tian Min Cheng,Xin Ze Ran,Guo He Yan,Yong Ping Su,Rong Qing LiuRen Shan Sun1,Xiao Hong Chen2,Tian Min Cheng1,Xin Ze Ran1,Guo He Yan1,Yong Ping Su1,Rong Qing Liu1,1National Key Laboratory of Trauma,Burns and Combined Injury,Third Military Medical University, 2Department of Pharmacology,Third Military Medical University,Chongqing 400038,China |
| Abstract: | AIM:To explore the mechanism of Bletilla Striata in promoting wound healing by studying the effects of some factors of Bletilla Striata in the healing of rat wound. METHODS:Rats were anesthetized, and two skin excision wounds 1.6 cm in diameter were created on the back of each rat bilateral spine, one of which was randomly locally treated with Bletilla Striata solution, or, two full thickness skin excision wounds 8 cm in length were made and buried with polyvinyl alcohol sponge, random side of which was injected with Bletilla Striata solution.RESULTS:Residual area percentage of wound in the treatment group was significantly lower than that of the control group at 3 (or 5), 7, 10, 14 and 21 days after wound, and wound healing time was advanced by 2.5 days. At 3, 5 and 7 days after wound, the contents of wound tissue protein and hydroxyproline and the number of macrophages in wound in the treatments group were significantly increased, as compared with those of the control group. |
| Keywords: | Bletilla Striata improves the healing speed and quality probably by improving the number of macrophage in wound. |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |