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| 自发性高血压大鼠左心室癌基因c－myc的表达 | |
| 引用本文： | 陈松苍,陈达光,王华军,林应锵,包幼迪,晋学庆. 自发性高血压大鼠左心室癌基因c－myc的表达[J]. 福建医科大学学报, 1994, 0(3) |
| 作者姓名： | 陈松苍 陈达光 王华军 林应锵 包幼迪 晋学庆 |
| 作者单位： | 福建医学院高血压研究室，福建医学院基因工程研究室 |
| 摘 要： | 探讨在体情况下癌基因ｃ－ｍｙｃ与心肌肥厚的关系，研究已有心肌肥厚雄性４０周龄自发性高血压大鼠（ＳＨＲ）和年龄、性别相配的Ｗｉｓｔａｒ京都种（ＷＫＹ）大鼠左心室ｃ－ｍｙｃ基因表达变化。Ｎｏｒｔｈｅｒｎ杂交的结果显示ＳＨＲ左室肌ｃ－ｍｙｃ表达量明显比ＷＫＹ高。左室增强的ｃ－ｍｙｃ表达可能在ＳＨＲ左室肥厚形成中起重要作用。 |
| 关 键 词： | 自发性高血压大鼠，左室肥厚，癌基因，c－myc |
Expression of Proto-oncogene c-myc in Left Ventricle of Spontaneously Hypertensive Rats |
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| Chen Songcang, Chen Daguang, Wang Huajun,et al. Expression of Proto-oncogene c-myc in Left Ventricle of Spontaneously Hypertensive Rats[J]. Journal of Fujian Medical University, 1994, 0(3) | |
| Authors: | Chen Songcang Chen Daguang Wang Huajun et al |
| Abstract: | To explore the relation between proto-oncogene c-myc expression in vivo and cardiac hypertrophy, we investigated the change of proto-oncogene c-myc expression in left ventricle spontaneously hypertensive rats (SHR) with ventricular hypertrophy at 40-week-old and sex,age-matched Wistar-kyoto (WKY) rats. The results by northern hybridization showed that the expression of c-myc in left ventricle in SHR was significantly higher than that in WKY.The enhanced c-myc expression in SHR heart may play an important role in the development of left hypertrophy. |
| Keywords: | rats. inbred SHR hypertrophy. left ventricular proto-oncogene c-myc |
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