胃肠道间质瘤48例临床诊治探讨

目的探讨胃肠道间质瘤的临床诊断和治疗方法。方法回顾性分析我科收治的48例患者的病史资料及病理结果。结果48例临床表现均无特异性，行CT、内镜、腹部超声等检查发现肿瘤，其中位于胃32例，空肠、回肠10例，十二指肠2例，结肠2例，直肠1例，肠系膜1例，均行外科手术治疗，CD117阳性率为91．7％（44／48），CD34表达阳性率为75％（36／48）。结论胃肠道间质瘤临床表现无明显特异性，术前明确诊断较为困难，目前手术仍是唯一有效的治疗方式，伊马替尼的应用可以改善预后。

Diagnosis and Treatment of 48 Cases of Gastrointestinal Stromal Tumors

Objective To investigate the clinical diagnosis and treatment of gastrointestinal stromal tumors （GIST）. Methods Forty-eight patients with GIST in our department were analysed retrospectively. Results All patients had no clinical specificity; the tumor were found by CT, endoscope and abdominal ultrasonic imaging, of which 32 cases in stomach, 10 cases in jejunum and ileum, 2 cases in duodenum, 2 cases in colon, one case in rectum, one case in mesentery; all patients received surgical operation. The positive rate of CD117 was 91.7% （44/48） and the express positive rate of D34 was 75% （36/48）, Conclusion Preoperative diagnosis of GIST is difficult due to the unconspicuous specificity of clinical manifestation. Surgical operation is the only valid therapy for GIST and the application of imatinib can improve the prognosis.