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Role of chance in familial aggregation of colorectal cancer |
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| Authors: | Katballe N Bentzen S M Christensen M Wikman F P Ørntoft T Laurberg S |
| Affiliation: | Surgical Research Unit 900, Department or Surgery L, Aarhus University Hospital, Aarhus Amtssygehus, Aarhus, Denmark. |
| Abstract: | A prospective population-based study recorded family trees of 77 colorectal cancer patients younger than 50 years of age. Using mathematical modeling of population age-incidence data, we estimate that 1 (95% confidence limits 0 and 3) of these families is expected to meet the Amsterdam criteria I for HNPCC due to chance clustering of colorectal cancer. |
| Keywords: | HNPCC hereditary non-polyposis colorectal cancer Amsterdam criteria incidence coincidence |
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