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| 万古霉素血药浓度监测的临床应用 | |
| 引用本文： | 黄义泽,毛名扬,袁孔现. 万古霉素血药浓度监测的临床应用[J]. 中国感染与化疗杂志, 2011, 11(4): 295-298 |
| 作者姓名： | 黄义泽 毛名扬 袁孔现 |
| 作者单位： | 1. 安徽省铜陵市人民医院感染科,244000 2. 安徽省铜陵市人民医院临床药学室,244000 |
| 基金项目： | 安徽省铜陵市卫生局科研资助项目 |
| 摘 要： | 目的 探讨万古霉素血药浓度监测的临床应用,以指导临床合理用药.方法 收集临床上有病原学依据而应用万古霉素病人的血液标本,应用高效液相色谱法(HPLC)测定万古霉素血药浓度,实现个体化给药.结果 18例病人进行万古霉素血药浓度监测,设为治疗组,其中4例病人血药浓度在治疗窗范围内,未调整给药方案;14例病人经调整给药后,血药浓度亦控制在正常范围内.34例病人未进行万古霉素血药浓度测定,设为对照组.治疗组与对照组病人治愈率分别为100%和76.5%,两组疗效差异有统计学意义(P<0.05);肾毒性发生率分别为0和26.5%,两组肾毒性差异有统计学意义(P<0.05);两组均未出现耳毒性病人.结论 应用高效液相色谱法测定万古霉素血药浓度,根据血药浓度制定个体化给药方案,能提高疗效,减少不良反应. |
| 关 键 词： | 高效液相色谱法 万古霉素 血药浓度 个体化 临床应用 |
Clinical application of drug monitoring of vancomycin |
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| HUANG Yize,MAO Mingyang,YUAN Kongxian. Clinical application of drug monitoring of vancomycin[J]. Chinese Journal of Infection and Chemotherapy, 2011, 11(4): 295-298 | |
| Authors: | HUANG Yize MAO Mingyang YUAN Kongxian |
| Affiliation: | HUANG Yize,MAO Mingyang,YUAN Kongxian.(Department of Infectious Diseases,Tongling People's Hospital,Anhui Tongling 244000,China) |
| Abstract: | Objective To investigate the clinical application of drug monitoring to guide rational use of vancomycin.Methods Blood samples were collected from the patients with microbiologically confirmed infection,who were treated with vancomycin.High-performance liquid chromatography(HPLC) was used to determine the concentration of vancomycin for individualized therapy.Results Fifty-two patients were divided into two groups: treatment group(n=18) and control group(n=34).The blood concentration of vancomycin was monit... |
| Keywords: | high-performance liquid chromatography vancomycin serum concentration individualized therapy clinical application |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |