代谢重编程对小胶质细胞功能的调节作用

免疫细胞通过改变营养物质的摄取和代谢酶的活性,以支持免疫激活的代谢需求,这一过程被称为免疫细胞的代谢重编程。小胶质细胞是脑内重要的免疫细胞之一,其表达大多数能源代谢途径底物的基因。越来越多研究证实小胶质细胞代谢具有高度灵活性,且调控代谢可调节小胶质细胞免疫功能,进而影响神经炎性疾病的发展与转归。本文综述了小胶质细胞在不同微环境下的代谢特征,以及小胶质细胞代谢重编程对其免疫功能的调节及机制。

The effect of metabolic reprogramming on microglial function

Immune cells support the metabolic needs of immune activation by changing the activity of metabolic enzymes and nutrient uptake,and this process is called metabolic reprogramming of immune cells. Microglia is one of the important immune cells in the brain,and it expresses most of the genes of energy substrate metabolism pathway. More and more studies have confirmed that the metabolism of microglia is highly flexible,and the regulation of metabolism can affect the immune function of microglia,and even affect the development and prognosis in neuroinflammatory diseases. This review focused on the metabolic characteristics of microglia in different environments,and discussed the effect and mechanism of microglia metabolic reprogramming on its immune function.