精神分裂症患者脑源性营养因子与临床特征的关系

目的：探讨精神分裂症患者脑源性营养因子（BDNF）与临床特征的相关性。方法：符合美国精神障碍诊断与统计手册第4版（DSM-IV）诊断标准的精神分裂症患者173例，并选择年龄、性别相匹配的健康居民作为对照，以阳性和阴性症状量表（PANSS）评估精神症状，用酶联免疫吸附法检测血清BDNF水平。结果：患者组血清BDNF水平（9．8±1．9）μg／L显著低于正常对照组（11．8±2．5）μg／L，（t=-7．6．v=322，P〈0．01）；女性患者血清BDNF水平（10．4±2．1）μg／L显著高于男性组（9．6±1．8）μg／L，（t=2．3，v=154，P〈0．05）；氯氮平治疗的患者BDNF（10．1±1．6）μg／L显著高于利醅酮治疗者（8．9±2．6）μg／L，（F=3．1，v=2．P〈0．05）；患者BDNF水平与年龄、总病程、PANSS量表中阴性症状分呈显著负相关（r=-0．2，-0．16，-0．14，P〈0．05）,结论：精神分裂症患者血清BDNF水平显著下降；BDNF存在着性别差异，年龄越大、病程越长、阴性症状越重BDNF越低，接受氯氮平治疗患者BDNF高于利酪酮组.

A control study of relationship between clinical features and serum levels of brain derivedneurotrophic factors in chronic schizophrenic patients

Objective:To investigate the relationship between clinical features and serum levels of brain derived neurotrophic factors(BDNF) in chronic schizophrenic patients. Method:173 schizophrenic inpatients who met the diagnostic criteria of DSM-IV,were evaluated with the Positive and Negative Syndrome Scale(PANSS).With the method of Sandwish ELISA,serum BDNF levels were detected in schizophrenic patients and normal controls matched with sex and age. Results:Serum BDNF levels were markedly lower in patients group ...