| 促渗剂对光甘草定体外经皮渗透效果的影响 |
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| 引用本文： | 王艳,王丽峰,席亚斌,张佩雯,贺浩珂,李青,张思培,芦婕,张艳军. 促渗剂对光甘草定体外经皮渗透效果的影响[J]. 中国实验方剂学杂志, 2015, 21(6): 14-16 |
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| 作者姓名： | 王艳 王丽峰 席亚斌 张佩雯 贺浩珂 李青 张思培 芦婕 张艳军 |
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| 作者单位： | 天津中医药大学 中药学院, 天津市中药化学与分析重点实验室, 天津 300193,天津中医药大学 中药学院, 天津市中药化学与分析重点实验室, 天津 300193,天津中医药大学 中药学院, 天津市中药化学与分析重点实验室, 天津 300193,天津中医药大学 中药学院, 天津市中药化学与分析重点实验室, 天津 300193,天津中医药大学 中药学院, 天津市中药化学与分析重点实验室, 天津 300193,天津中医药大学 中药学院, 天津市中药化学与分析重点实验室, 天津 300193,天津中医药大学 中药学院, 天津市中药化学与分析重点实验室, 天津 300193,天津中医药大学 中药学院, 天津市中药化学与分析重点实验室, 天津 300193,天津中医药大学 中药学院, 天津市中药化学与分析重点实验室, 天津 300193 |
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| 基金项目： | 天津市高等学校科技发展基金计划项目(20110206);天津市西青区科技型中小企业发展专项(XQKH2013-011);天津中医药大学大学生科技创新基金项目(CXJJ2013C14) |
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| 摘 要： | ![]()
目的:考察促渗剂对光甘草定体外经皮渗透性能的影响,为该化合物经皮给药系统的开发提供参考。方法:采用HPLC测定光甘草定含量,流动相乙腈-水-冰乙酸(55∶44∶1),检测波长282nm。选取小鼠背部皮肤,通过Franz垂直扩散池考察光甘草定的透皮性能,考察氮酮、冰片、丙二醇对光甘草定乳剂透皮吸收的影响。结果:光甘草定的透皮吸收率较低,促渗剂能有效使其透过皮肤。不同促渗剂对光甘草定促透作用顺序为5%氮酮组>5%丙二醇组>5%冰片组>单体组,稳态渗透速率分别为4.938,3.041,2.950,2.583μg·cm-2·h-1,滞后时间依次为0.056,0.180,0.059,0.167h。结论:不同促渗剂均能促进光甘草定的经皮渗透效果,以氮酮为最佳。
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| 关 键 词： | 光甘草定 光果甘草 促渗剂 透皮吸收试验 稳态渗透速率 滞后时间 |
| 收稿时间： | 2014-06-18 |
Influence of Permeation Enhancers on in vitro Transdermal Permeation of Glabridin |
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| WANG Yan,WANG Li-feng,XI Ya-bin,ZHANG Pei-wen,HE Hao-ke,LI Qing,ZHANG Si-pei,LU Jie and ZHANG Yan-jun. Influence of Permeation Enhancers on in vitro Transdermal Permeation of Glabridin[J]. China Journal of Experimental Traditional Medical Formulae, 2015, 21(6): 14-16 |
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| Authors: | WANG Yan WANG Li-feng XI Ya-bin ZHANG Pei-wen HE Hao-ke LI Qing ZHANG Si-pei LU Jie ZHANG Yan-jun |
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| Affiliation: | Tianjin Key Laboratory of Chemistry and Analysis of Traditional Chinese Medicine(TCM), College of TCM, Tianjin University of TCM, Tianjin 300193, China,Tianjin Key Laboratory of Chemistry and Analysis of Traditional Chinese Medicine(TCM), College of TCM, Tianjin University of TCM, Tianjin 300193, China,Tianjin Key Laboratory of Chemistry and Analysis of Traditional Chinese Medicine(TCM), College of TCM, Tianjin University of TCM, Tianjin 300193, China,Tianjin Key Laboratory of Chemistry and Analysis of Traditional Chinese Medicine(TCM), College of TCM, Tianjin University of TCM, Tianjin 300193, China,Tianjin Key Laboratory of Chemistry and Analysis of Traditional Chinese Medicine(TCM), College of TCM, Tianjin University of TCM, Tianjin 300193, China,Tianjin Key Laboratory of Chemistry and Analysis of Traditional Chinese Medicine(TCM), College of TCM, Tianjin University of TCM, Tianjin 300193, China,Tianjin Key Laboratory of Chemistry and Analysis of Traditional Chinese Medicine(TCM), College of TCM, Tianjin University of TCM, Tianjin 300193, China,Tianjin Key Laboratory of Chemistry and Analysis of Traditional Chinese Medicine(TCM), College of TCM, Tianjin University of TCM, Tianjin 300193, China and Tianjin Key Laboratory of Chemistry and Analysis of Traditional Chinese Medicine(TCM), College of TCM, Tianjin University of TCM, Tianjin 300193, China |
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| Abstract: | ![]()
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| Keywords: | glabridin Glycyrrhiza glabra penetration enhancers transdermal absorption test permeation rate of steady state lag time |
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