吗丁啉治疗胃食管反流相关性支气管哮喘疗效观察

目的：观察吗丁啉对胃、食管反流相关性支气管哮喘的疗效。方法：对50例胃、食管反流相关性支气管哮喘患，在支气管哮喘急性发作时给予常规对症治疗的同时，给予口服吗丁啉20mg,tid；伴有慢性胃炎加服雷米替丁0.3g、阿莫西林0.5g及灭滴灵0.2g,tid；有胃酸过多夜间加服洛赛克（losec)20mg。4wk为一个疗程，第一个疗程结束后，停药观察1－4wk，病情复发继服第二个疗程。结果：第一个疗程结束后，有45例病人停止发病，观察6mon病情未复发。5例在停药1－4wk病情复发，继服第二个疗程后。5例在停药1－4wk病情复发，继服第二个疗程后，有4例停止发病，随访6mon未复发，1例发病次数减少一半。结论：吗丁啉用以预防和治疗胃、食管反流相关性支气管哮喘具有良好效果。

Effect of motilium on 50 cases of bronchial asthma associated with gastroesophageal reflux

AIM:To observe the effect of motilium on bronchial asthma associated with gastroesophageal reflux(GER BA). METHODS:50 cases of GER BA, were treated with routine anti asthma and motilium 20 mg tid,ranitidine 0.3 g,amoxicillin 0.5 g and metronidazolum 0.2 g tid for chronic gastritis cases, and losec 20 mg for the gastric acid rdflux at night. The treatment lasted for 1-4 wk, and then stopped to observe the response of the treatmeat. The recurrent cases would be treated as the above again. RESULTS:45 cases were cured in the 4 wk,no case recrudesced in 6 mon. 5 cases needed another the treatment for 1-4 wk since the recurrence, and 4 of the 5 cases were cured. CONCLUSION: Motilium has a good curative effect in preventing and curing bronchial asthma associated with gastroesophageal reflux.entfor1 -4wksin