有高血压家族史血压正常的青少年血清抵抗素测定及临床意义

目的:探讨有高血压家族史但血压正常的青少年血清抵抗素的变化。方法:研究对象为30例有高血压家族史、本人血压正常的青少年(家族史阳性组,FH+组)和30例无高血压家族史、血压正常的青少年(对照组,FH-组),测定其身高、体重、体重指数(BMI)、血压、空腹血糖(FBG)、血总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)和血清抵抗素(Resistin)。结果:FH+组青少年的BMI、收缩压、FBG、TC、LDL-C和血清抵抗素均高于FH-组,差异有统计学意义(P<0.05)。血清抵抗素水平与收缩压(SBP)和FBG呈正相关(P<0.05)。结论:有高血压家族史的青少年即使在血压尚处于正常范围时,已发生血清抵抗素水平升高,血清抵抗素水平可能与血压相关。

Detection of serum resistin and clinical significance in normotensive adolescents with family history of hypertension

Objective: To explore the changes of serum resistin in normotensive adolescents with family history of hypertension. Methods: 30 normotensive adolescents with family history of hypertension ( positive group,FH + group) and 30 normotensive adolescents without family history of hypertension ( control group,FH group) were selected. Height,weight,body mass index ( BMI) , blood pressure,fasting blood glucose ( FBG) ,total cholesterol ( TC) ,cholesteroltriglyceride ( TG) ,low density lipoprotein cholesterol ( LDL C) ,high density lipoprotein cholesterol ( HDL C) and resistin were detected. Results: BMI,systolic blood pressure,FBG,TC, LDL C and serum resistin in FH + group were significantly higher than those in FH group ( P < 0. 05) . There was a positive correlation between serum resistin level and systolic blood pressure,FBG ( P < 0. 05) . Conclusion: The level of serum resistin increases in normotensive adolescents with family history of hypertension. Serum resistin level may be related to blood pressure.