快杀灵对雄性小鼠精子毒性的实验研究

[目的]研究快杀灵对雄性小鼠精子的毒性作用。[方法]用不同总剂量 (9.1mg/kg、18.2mg/kg、36.4mg/kg)快杀灵给小鼠经口连续灌胃10天染毒 ,于末次染毒后25d处死小鼠 ,称重睾丸、附睾 ,并计算精子活动度、精子数及畸形率。[结果]精子数量在18.2mg/kg、36.4mg/kg组与对照组比较差异有显著性 (P<0.01)。精子畸形率在36.4mg/kg组与对照组差异有显著性 (P<0.01) ,精子活动度在3个实验组与阴性对照组差异均有显著性 (P<0.01) ,睾丸、附睾重量与阴性对照组比较 ,差异有显著性 (P<0.01)。[结论]快杀灵对小鼠具有一定的精子毒性作用

Study on Effects of Kuaishaling on Sperm Toxicity in Mice

Objective Effects of Kuaishaling at different doses on sperm toxicity in male mice were studied.[Methods] The agent was administrated to mice at different doses(9.1mg/kg,18.2mg/kg,36.4mg/kg)by gavage once a day for successive ten days.The mice were sacrificed on the35th day after following the first gavage.The weight of testicle and epididymis,the quantity,activity and morphology of sperms were examined.[Results] The spermatozoa count had significant differentce between18.2mg/kg,36.4mg/kg and control groups(P<0.01).Sperm deformation ratio had significant difference between36.4mg/kg and the negative control group(P<0.01).The spermatozoa motility changed significantly compared with the negative control group(P<0.01).Com-pared with the negative control group,significant difference in the weight of testicle and epididymis was found(P<0.01).[Conclusions] Kuaishaling has sperm toxicity to male mice.