广州市1 420名体检者高尿酸血症患病率及危险因素调查

目的对社区65岁及以上无症状高尿酸血症老年人群进行生活方式干预，并对干预结果进行效果评价。方法将上海市打浦桥社区2013年65岁及以上体检人群中227例无症状高尿酸血症者随机分为干预组和对照组。干预组通过家庭医生团队进行为期2年的行为干预，包括建立电子健康档案，进行健康评估、生活方式指导，随访干预组和对照组的血尿酸水平及相关指标，并进行比较。结果干预前，不同性别两组研究对象的年龄、BMI、腰围、血压、血生化指标等差异无统计学意义[血尿酸：男性组(444.00±18.03)、(442.48±14.60)μmol/L，t=0.432，P=0.667；女性组(385.36±16.05)、(389.39±17.48)μmol/L，t=-1.309，P=0.193]。干预1、2年后，干预组血尿酸浓度均低于对照组，差异有统计学意义[血尿酸：1年后，男性组(419.45±24.83)、(437.01±24.44)μmol/L，t=-3.420，P= 0.001；女性组(354.68±30.26)、(374.35±29.53)μmol/L，t=-3.588，P=0.000。2年后，男性组(408.73±34.30)、(435.49±41.31)μmol/L，t=-3.381，P=0.001；女性组(317.47±35.81)、(364.58±43.63)μmol/L，t=-6.420，P=0.000]。同时，干预组的空腹血糖、三酰甘油水平较对照组更低，差异有统计学意义(P均 < 0.05)。结论对无症状高尿酸血症者的行为干预，对高尿酸血症的控制具有一定的积极作用。

Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2

ObjectiveTo intervene in living behavior and food habits of patients with asymptomatic hyperuricemia over 65 year-old in a community of Shanghai and study the effect.MethodsA total of 227 patients over 65 year-old from Dapuqiao community in Shanghai in 2013 were selected and randomly assigned into two groups:the intervention group and control group.Behavioral intervention was performed in the intervention group by general practitioner teams, including the establishment of electronic health records, health assessments, guidance on healthy lifestyles, while no above intervention was given in the control group in two years.The serum uric acid and other related test results were compared between the two groups.ResultsBefore the intervention, there were no significant differences in age, BMI, waist circumference, blood pressure and biochemical indexes between the two groups.The levels of serum uric acid among males:(444.00±18.03)and(442.48±14.60)μmol/L, t=0.432, P=0.667.The levels of serum uric acid among females:(385.36±16.05)and(389.39±17.48)μmol/L, t=-1.309, P=0.193.After 1 year and 2 years′ behavioral intervention, the serum uric acid of the intervention group were significantly lower than that of the control group.The levels of serum uric acid at 1 year after behavioral intervention:the male group were (419.45±24.83) and(437.01±24.44)μmol/L, t=-3.420, P=0.001 while the female group were (354.68±30.26) and (374.35±29.53)μmol/L, tS=-3.588, P=0.000.The levels of serum uric acid at 2 years after behavioral intervention:the male group were (408.73± 34.30) and (435.49±41.31)μmol/L, t=-3.381, P=0.001 while the female group were (317.47±35.81) and (364.58±43.63)μmol/L, t=-6.420, P=0.000. Meanwhile, the levels of fasting blood-glucose and triglyceride in the intervention group were significantly lower than those in the control group(All P < 0.05).ConclusionThe behavioral intervention can decrease serum uric acid in patients with asymptomatic hyperuricemia, which suggests that the intervention strategy is effective in this regard.