ZDHHC9 promotes colon tumor growth by inhibiting effector T cells |
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| Authors: | Xiaodan Chong Lingxi Zhu Dong Yu Shasha Chen Guang Wang Qingzhuo Yu Xianwei Ma Jing Xu Haitao Chen Huazhang An |
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| Affiliation: | 1.Clinical Cancer Institute, Translational Medicine Center, Naval Medical University, Shanghai 200433, P.R. China;2.Thoracic Surgery Department, The General Hospital of Western Theater Command, Chengdu, Sichuan 610083, P.R. China;3.Center of Translational Medicine, Naval Medical University, Shanghai 200433, P.R. China;4.Department of Geriatrics, Changhai Hospital, Naval Medical University, Shanghai 200433, P.R. China |
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| Abstract: | ![]()
Zinc finger DHHC-type palmitoyltransferase 9 (ZDHHC9) has been reported to play an important role in the occurrence and development of several types of cancer. However, its effects on colon cancer growth remain unclear. Using Gene Expression Profiling Interactive Analysis and Tumor Immune Estimation Resource, data obtained from The Cancer Genome Atlas were analyzed, and the results showed that ZDHHC9 was highly expressed in colon cancer and that patients with higher ZDHHC9 expression levels had a worse prognosis. Inhibition of ZDHHC9 expression promoted the proliferation of colon cancer cells in vitro but decreased their growth in vivo. Additionally, inhibition of ZDHHC9 expression in cancer cells enhanced CD8+ T cell-mediated cytotoxicity in vitro and increased CD8+ T infiltration and activation in vivo. Furthermore, ZDHHC9 promoted IFN-γ-induced JAK/STAT1 activation and upregulated programmed death-ligand 1 (PD-L1) expression in colon cancer cells. In conclusion, the present findings showed that ZDHHC9 promoted colon cancer growth by upregulating the expression of PD-L1 and inhibiting the function of CD8+ T cells. |
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| Keywords: | zinc finger DHHC-type palmitoyltransferase 9 immune infiltration programmed death-ligand 1 JAK/STAT1 colon cancer |
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