创面愈合过程中内源性EGF变化的研究

为探讨创面愈合的机理，本实验采用免疫组织化学方法，对大鼠中厚皮片供皮区创面愈合过程中第４、８、１２和１６天创面内源性表皮生长因子（Ｅｐｉｄｅｒｍａｌｇｒｏｗｔｈｆａｃｔｏｒ，ＥＧＦ）的变化进行了研究。结果表明，创面愈合过程中内源性ＥＧＦ含量表现有规律性变化，以伤后第８天含量最多，伤后早期和晚期次之，创面愈合后其含量进一步减少。结论：创面愈合过程中，内源性ＥＧＦ的变化促进了创面愈合，是创面愈合的机理之一，结合内源性ＥＧＦ变化，合理外用ＥＧＦ对创面愈合可能会取得促进的效果。

Study on the change of endogenous EGF during wound healing

In order to explore the pathogenesis of wound healing,We have observed the changes of endogenous epidermal growth factor (EGF)during the process of rat spliting thickness cutaneous wound healing on the day of 4,8,12 and 16 after wound with immunohistochemistry method.The results showed that the change of endogenous EGF during the process of wound healing appeared to be in the regular pattern,the peak of endogenous EGF expression is on the 8th day after wound, the next is on the both early and late stages of wound,the endogenous EGF expression was decreased remarkbaly when the wound healing was finished.It suggested that the change of endogenous EGF expression had promoted wound healing,which is one of the pathogenesis of wound healing.Rational use EGF combined with the change of endogenous EGF may achieve better results during the wound healing.