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| 以玻璃酸钠为媒介对布洛芬体外释放及透皮吸收的影响 | |
| 引用本文： | 李琦,王凤山,凌沛学,张天民. 以玻璃酸钠为媒介对布洛芬体外释放及透皮吸收的影响[J]. 中国医院药学杂志, 2007, 27(9): 1235-1238 |
| 作者姓名： | 李琦 王凤山 凌沛学 张天民 |
| 作者单位： | 1. 山东省胸科医院药剂科,山东,济南,250013;山东大学药学院生化与生物技术药物研究所,山东,济南,250012 2. 山东大学药学院生化与生物技术药物研究所,山东,济南,250012 |
| 摘 要： | 目的:研究以玻璃酸钠为媒介对布洛芬释放的影响因素和透皮吸收的影响。方法:配制不同的布洛芬溶液,采用改良的Franz扩散池,测定药物的体外渗透速率。结果:增加溶液的黏度能减慢布洛芬的释放速率,其释放速率随着玻璃酸钠浓度的增加而降低,随着布洛芬浓度的增加而提高。玻璃酸钠在水溶液中能抑制布洛芬的透皮吸收。结论:布洛芬的释放速率与溶液的黏度和药物浓度有关,玻璃酸钠是一种良好的外用药物媒介。 |
| 关 键 词： | 玻璃酸钠 布洛芬 药物释放 透皮吸收 |
| 文章编号： | 1001-5213（2007）09-1235-04 |
| 修稿时间： | 2007-04-15 |
Influence of sodium hyaluronate as vehicle on ibuprofen release and transdermal absorption in vitro |
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| LI Qi,WANG Feng-shan,LING Pei-xue,ZHANG Tian-min. Influence of sodium hyaluronate as vehicle on ibuprofen release and transdermal absorption in vitro[J]. Chinese Journal of Hospital Pharmacy, 2007, 27(9): 1235-1238 | |
| Authors: | LI Qi WANG Feng-shan LING Pei-xue ZHANG Tian-min |
| Affiliation: | 1. Department of Pharmacy, The Chest Hospital of Shandong Province, Shandong Jinan 250013, China; 2. Institute of Biochemical and Biotechnologicol Drug, Pharmacy School of Shandong University, Shandong Jinan 250012, China |
| Abstract: | OBJECTIVE To study the influence factors of ibuprofen release and transdermal absorption with sodium hyaluronate as vehicle.METHODS The penetration rates of ibuprofen were determined with modified Franz diffusion cell in different solutions.RESULTS The increase of solution viscosity could decrease the release rate of ibuprofen.The release rates of ibuprofen decreased with the concentrations of sodium hyaluronate increased and increased with the concentrations of ibuprofen increased.Sodium hyaluronate could inhibit the skin penetration of ibuprofen in aqueous solution.CONCLUSION The release rate of ibuprofen is concerned with solution viscosity and drug concentration.Sodium hyaluronate is a good vehicle in drug external use. |
| Keywords: | sodium hyaluronate ibuprofen drug release transdermal absorption |
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