慢性阻塞性肺疾病合并肺纤维化血气分析及肺功能指标的临床观察

目的了解慢性阻塞性肺疾病（COPD）合并肺间质纤维化（PIF）的血气及肺功能特点,探讨其临床意义。方法我院2000～2006年诊断的COPD合并肺间质纤维化10例及随机抽取同期单纯慢性阻塞性肺疾病13例患者的PaO2、PaCO2、FEV1、FVC、FEV1%、DLCO进行对比分析。结果COPD合并肺间质纤维化低氧血症更明显（P〈0.05）。二氧化碳潴留则有所减轻。FEV1%下降不如单纯COPD明显（P〈0.05）。FVC下降较单纯COPD明显（P〈0.05）DLCO显著降低（P〈0.05）。结论慢性阻塞性肺疾病合并肺间质纤维化具有独特的临床特点,兼有二者的特征。

Clinical study on artery blood gas analysis and pulmonary function of chronic obstructive pulmonary disease with pulmonary interstitial fiberosis

Objective To explore the blood gas and pulmonary function in chronic obstructive pulmonary disease(COPD) with pulmonary interstitial fiberosis. Methods 10 COPD patients following with pulmonary interstitial fiberosis and 13 patients with COPD were retrospectively compared (PaO2,PaCO2,FEV1,FVC,FEV1%,DLCO). Results COPD with pulmonary interstitial fiberosis had hypoxemia (P<0.05),but less CO2 retention(P<0.05),less depress with FEV1%(P<0.05),and more depress with FVC and DLCO(P<0.05). Conclusions COPD and PIF are different disease. When they coexist in some patients,their clinical manifestations have characteristics of both disease.