多西他赛联合替加氟和顺铂治疗晚期胃癌疗效观察

目的：观察多西他赛联合顺铂、替加氟（DCF1方案）治疗晚期胃癌的疗效和不良反应。方法：采用DCFt方案治疗66例晚期胃癌患者。多西他赛75m／m^2，d1；顺铂75m／m^2，d1；替加氟20mg／kg，静脉滴注d。天，3周1个周期，至少2个周期。结果166例晚期胃癌中，完全缓解（CR）0例，部分缓解（PR）36例（54．5％），稳定（SD）16例（24．2％），进展（PD）14例（21．2％）。中位肿瘤进展时间为6．1个月（3．5—11．5个月），中位总生存期为11．2个月（6．0—14．5个月）。最常见的不良反应为骨髓抑制、消化道反应及可逆性体液潴留，不良反应多为Ⅰ-Ⅱ度，无Ⅳ度不良反应发生。骨髓抑制以自细胞减少为特点，血小板减少及贫血较轻。消化道反应主要表现为恶心呕吐、腹泻便秘。无治疗相关性死亡。结论：DCFt方案是治疗晚期胃癌安全有效的化疗方案。

Efficacy of combination chemotherapy with docetaxel plus cisplatin and Ftorafur in treatment of patents with advanced gastric cancer

Objective：To assess the efficacy and safety of docetaxel plus cisplatin and Ftorafur in treatment of patients with advanced gastric cancinoma. Methods： Thirty - three patients with recurrent or metastatic gastric adenocarcinoma were enrolled and received doeetaxel （75mg/m^2, d1 ） plus cisplatin （ 75mg/m^2, d1 ） followed by Ftorafur （20 mg/kg ,continous iv gtt d1-5 ）. The treatment was repeated every 3 weeks. Results： All the thirty -three patients enrolled were evaluated for response and toxicity. The overall response rate was 54.5% with complete and partial response rates of 0 and 54.5% , respectively. The median overall survival time was 11.2 months ,and the median time to progress was 6.1 months . There was no any grade - Ⅳ toxicity, but grade - Ⅲ diarrhea in 2 patients （ 6.0% ） ,grade - Ⅲ leukopenia in 3 patients （9.0%）, and grade - Ⅲ vomiting in 8 patients （ 24.0% ）. Conclusion： Combination regimen of docetaxel plus cisplatin and 5 - fluorouracil is well tolerable and shows notable activity as first - line reament in metastatic carcinoma of the stomach.