| 苯巴比妥-聚乙烯吡咯烷酮共沉淀物的研究 |
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| 引用本文： | 李茂星,谢景文,区静,葛欣,何晓英,马慧萍.苯巴比妥-聚乙烯吡咯烷酮共沉淀物的研究[J].药学实践杂志,1998,16(1):39-41. |
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| 作者姓名： | 李茂星 谢景文 区静 葛欣 何晓英 马慧萍 |
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| 作者单位： | 兰州军区总医院药材料, 兰州, 730050;兰州军区总医院药材料, 兰州, 730050;兰州军区总医院药材料, 兰州, 730050;兰州军区总医院药材料, 兰州, 730050;兰州军区总医院药材料, 兰州, 730050;兰州军区总医院药材料, 兰州, 730050 |
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| 摘 要： | 本实验用聚乙烯吡咯烷酮(PVPk=30)为载体,采用溶剂法将苯巴比妥分别制成3种不同比例的共沉淀物,比较共沉淀物、机械混合物和原药的溶解特性,结果表明,共沉淀物能极显著地提高原药的溶解度和溶出速率.
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| 关 键 词： | 梅氏蒸疗法 逆脊椎 生理弧度变态 脊椎病 |
Studies on coprecipitation of phenobarbital-PVP |
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| Li Maoxing,Xie Jingwen,Qu Jin,et al.Studies on coprecipitation of phenobarbital-PVP[J].The Journal of Pharmaceutical Practice,1998,16(1):39-41. |
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| Authors: | Li Maoxing Xie Jingwen Qu Jin |
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| Institution: | Department of Pharmacy, General Hospital of Lanzhou Military Command, Lanzhou 730050;Department of Pharmacy, General Hospital of Lanzhou Military Command, Lanzhou 730050;Department of Pharmacy, General Hospital of Lanzhou Military Command, Lanzhou 730050;Department of Pharmacy, General Hospital of Lanzhou Military Command, Lanzhou 730050;Department of Pharmacy, General Hospital of Lanzhou Military Command, Lanzhou 730050;Department of Pharmacy, General Hospital of Lanzhou Military Command, Lanzhou 730050 |
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| Abstract: | The coprecitation of phenobarbital-PVP was prepared by solvent method. The ratios of phenobarbital and PVP are 1:3 and 1:10. The statistical analysis of dissolution rates showed extremely significant difference (P<0.01) between pure drug and mechanical impurity, coprecitation; significant difference (0.01<P<0.05)between mechanical impurity and coprecitate and no difference between coprecindion of different rations (P>0.05) |
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| Keywords: | phenobarbital PVP coprecitation dissolution rate |
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