| 寻常型银屑病患者及正常人S100A6、S100A8、S100A9基因的研究 |
| |
| 引用本文： | 王妍敏,郑捷. 寻常型银屑病患者及正常人S100A6、S100A8、S100A9基因的研究[J]. 中国麻风皮肤病杂志, 2004, 20(2): 97-99 |
| |
| 作者姓名： | 王妍敏 郑捷 |
| |
| 作者单位： | 1. 上海第二医科大学附属新华医院呼吸科,200092
2. 上海第二医科大学附属瑞金医院皮肤科,200025 |
| |
| 基金项目： | 国家人类基因组南方研究中心资助 (CNCS - 99M - 1 2 ) |
| |
| 摘 要： | 目的：通过测定家族性寻常型银屑病患者和正常人中S100A6、S100A8和S100A9基因的外显子编码区序列，探索其与银屑病发病的关系。方法：从家族性寻常型银屑病患者和正常人的外周血中提取基因组DNA，用自动测序法测定S100A6、S100A8和S100A9基因的外显子编码区序列。结果：患者和正常对照组的S100A6、S100A8、S100A9基因外显子编码区序列均相同，未发现基因多态性。结论：S100A6、S100A8、S100A9基因的外显子编码区序列与家族性寻常型银屑病发病无相关性。
|
| 关 键 词： | 寻常型银屑病 正常人 S100A6 S100A8 S100A9 基因 外显子 发病机制 |
Ssequencing of S100A6, S100A8 and S100A9 genes in patients with psoriasis vulgaris and controls |
| |
| Wang Yanmin,Zheng Jie. Ssequencing of S100A6, S100A8 and S100A9 genes in patients with psoriasis vulgaris and controls[J]. China Journal of Leprosy and Skin Diseases, 2004, 20(2): 97-99 |
| |
| Authors: | Wang Yanmin Zheng Jie |
| |
| Affiliation: | Wang Yanmin,Zheng Jie. Department of Dermatology,Ruijin Hospital,Shanghai Second Medical University,Shanghai,200025 |
| |
| Abstract: | Objective: To determine the gene sequence of S100A6, S100A8 and S100A9 in patients with psoriasis vulgaris and normal controls.Methods: DNA was extracted from peripheral blood of patients with psoriasis vulgaris and normal controls. The sequences of the coding regions of S100A6, S100A8 and S100A9 were measured by ABI377 DNA sequencer. Results: No mutation was found in S100A6, S100A8 and S100A9 gene exons. Conclusion: The coding regions of S100A6, S100A8 and S100A9 were not associated with psoriasis vulgaris. |
| |
| Keywords: | psoriasis vulgaris S100A6 S100A8 S100A9 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
