Hes1和 Notch1在食管癌组织中的表达及其意义

目的：探讨食管癌组织中Hes1和Notch1表达及其意义。方法采用免疫组织化学PV二部法检测50例食管癌肿瘤组织及20例癌旁正常食管组织中Hes1和Notch1的表达情况。结果食管癌组织中Hes1和Notch1的阳性表达率均显著低于癌旁正常组织（ P＜0．05）。 Hes1的表达与食管癌的淋巴结转移、临床分期、分化程度、侵袭程度密切相关（P＜0．05）。 Notch1的表达与食管癌的分化程度、侵袭转移密切相关。食管癌组织中Hes1和Notch1两者的表达呈正相关（ P＜0．05）。结论 Hes1和Notch1的异常表达与食管癌的发生、发展及侵袭转移密切相关，检测两种蛋白对于食管癌的早期诊断及预后判断有重要的意义。

Expression of Hes1 and Notch1 and Its Significance in Esophageal Cancer

Objective To study the expression of hes1 and notch1 and its significance in esophageal canc-er.Methods Immunohistochemistry PV department 2 method was used to detect the expression of hes1 and notch1 in 50 cases of esophageal cancer and 20 cases of adjacent normal esophageal tissue.Results The expression of hes1 and notch1 in esophageal cancer was lower than that in adjacent normal esophageal tissue（P〈0.05）.The expression of hes1 was closely related to lymphoid metastases,clinical stage,differentiated degree and depth of tumor invasion of esophageal cancer（P〈0.05）,and the expression of notch1 was closely related to the differentiated degree and depth of tumor inva-sion of esophageal cancer.The expression of hes1 and notch1 in esophageal cancer was positively correlated（ P〈0.05） . Conclusion The abnormal expressions of hes1 and notch1 are closely related to the occurrence,development,invasion and metastasis of esophageal cancer.Co-detection of hes1 and notch1 has significant effect on early diagnosis and progno-sis of esophageal cancer.