急性过敏性紫癜免疫功能的改变及中西医结合治疗对其调节作用

目的：观察急性过敏性紫癜（HSP）患儿免疫功能的改变。采用中西医结合治疗的方法，探讨中药银浮汤加转移因子对急性HSP患儿免疫功能的调节作用。方法：观察组（35例）采用中药银浮汤加转称因子治疗，并与采用常规治疗的对照组（35例）比较，治疗前后进行IgG、IgA、IgM、CD3、CD4、CD8、CD4／CD8比值,红细胞C3b受体花环率及免疫复合物花环率的检测。同时与40名健康儿童作健康对照，观察治疗前后免疫指标的变化。结果：治疗前（急性期）与健康对照组比较，IgA、IgM、CD4、CD4／CD8比值，红细胞C3b受体花环率均明显升高，而CD8明显下降，差异均有显著性（P＜0．01）。观察组与对照组治疗前后免疫指标的比较差异亦有显著性（P＜0．01），而观察组更优于对照组（P＜0．05）。观察组愈显率与对照组比较差异亦有显著性（P＜0．01）。结论：急性HSP存在多种免疫功能的改变，中药银浮汤加转移因子治疗，具有明显调节免疫功能的作用，是一种副作用少，复发率低，疗效显著的治疗方法。

Immune Functional Changes in Patients of Acute Henoch-Schonlein Purpura and Regulatory Effect of Integrated Traditional Chinese and Western Medicine on It

Objective: To observe the changes of immune function in children with acute Henoch-Schonlein purpura (AHSP) and the effects of integrated traditional Chinese and western medicine (TCM-WM) on it. Methods: Immunological criteria in TCM-WM group (n=35) treated by Yinfu Decoction (YFD) combined with transfer factor and 35 patients in the control group (n=35) treated by conventional treatment were observed and compared before and after treatment. Also the criteria were compared with those of 40 healthy subjects. Results: Before treatment, the levels of IgA, IgM, CD 4, CD 4/CD 8 ratio, rosette forming rate of RBC-C 3b receptor in patients were higher than those in the healthy subjects, but the levels of CD 8 was obviously lower, the difference was significant (P<0.01). The above-mentioned criteria were all improved in the two treated groups after treatment, and the improvement was more significant in the TCM-WM group than that in the control group (P<0.05). Besides, the cure-markedly effective rate in the former was better than that in the latter significantly (P<0.01). Conclusion: There exist multiple immune functional disturbance in AHSP patients. Combined treatment of YFD and transfer factor has obvious immune regulatory effect and is an effective therapy with few side-effects and low recurrence rate.