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Flavonoids from Iris songarica and their antioxidant and estrogenic activity
Authors:Moein Mahmood R  Khan Shabana I  Ali Zulfiqar  Ayatollahi Syed A  Kobarfard Farzad  Nasim Shama  Choudhary Muhammad I  Khan Ikhlas A
Affiliation:National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS, USA.
Abstract:A new dihydroflavonol, songaricol ( 1) and seven known flavonoids, ayamenin A ( 2), irisflavone A ( 3), 5,7-dihydroxy-2',6-dimethoxyisoflavone ( 4), irilin B ( 5), 5,3'-dihydroxy-7,8,2'-trimethoxyisoflavone ( 6) and irisoid A ( 7) were isolated from rhizome and roots of IRIS SONGARICA. Structure elucidation of 1 was achieved through extensive NMR and circular dichroism techniques. Compounds 1, 5 and 7 showed antioxidant activity in HL-60 cells (IC50 values of 21, 11 and 3.8 microg/mL), whereas 2, 5 and the previously isolated irisone B were able to show estrogenic response (EC50 values of 305.5, 159.7 and 322.0 microg/mL) in yeast cells expressing human estrogen receptor (ER-alpha).
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